A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
2016
Authors
Avramov Ivić, MilkaAntanasijevic, Jelena
Trišović, Nemanja
Antanasijevic, Davor
Lović, Jelena
Mijin, Dušan
Petrović, Slobodan D.
Article (Published version)
Metadata
Show full item recordAbstract
The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous pred...iction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
Keywords:
phenobarbital / paracetamol / voltammetry / chemometricsSource:
International Journal of Electrochemical Science, 2016, 11, 7, 5935-5951Publisher:
- Esg, Belgrade
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
- New approach in designing materials for energy conversion and energy storage systems (RS-172060)
- Development and Application of Methods and Materials for Monitoring New Organic Contaminants, Toxic Compounds and Heavy Metals (RS-172007)
DOI: 10.20964/2016.07.48
ISSN: 1452-3981
WoS: 000384905600050
Scopus: 2-s2.0-84978138152
Collections
Institution/Community
IHTMTY - JOUR AU - Avramov Ivić, Milka AU - Antanasijevic, Jelena AU - Trišović, Nemanja AU - Antanasijevic, Davor AU - Lović, Jelena AU - Mijin, Dušan AU - Petrović, Slobodan D. PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1941 AB - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode VL - 11 IS - 7 SP - 5935 EP - 5951 DO - 10.20964/2016.07.48 ER -
@article{ author = "Avramov Ivić, Milka and Antanasijevic, Jelena and Trišović, Nemanja and Antanasijevic, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D.", year = "2016", abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode", volume = "11", number = "7", pages = "5935-5951", doi = "10.20964/2016.07.48" }
Avramov Ivić, M., Antanasijevic, J., Trišović, N., Antanasijevic, D., Lović, J., Mijin, D.,& Petrović, S. D.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science Esg, Belgrade., 11(7), 5935-5951. https://doi.org/10.20964/2016.07.48
Avramov Ivić M, Antanasijevic J, Trišović N, Antanasijevic D, Lović J, Mijin D, Petrović SD. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951. doi:10.20964/2016.07.48 .
Avramov Ivić, Milka, Antanasijevic, Jelena, Trišović, Nemanja, Antanasijevic, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951, https://doi.org/10.20964/2016.07.48 . .