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A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode

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Authors
Avramov Ivić, Milka
Antanasijevic, Jelena
Trišović, Nemanja
Antanasijevic, Davor
Lović, Jelena
Mijin, Dušan
Petrović, Slobodan D.
Article (Published version)
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Abstract
The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous pred...iction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.

Keywords:
phenobarbital / paracetamol / voltammetry / chemometrics
Source:
International Journal of Electrochemical Science, 2016, 11, 7, 5935-5951
Publisher:
  • Esg, Belgrade
Projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
  • New approach in designing materials for energy conversion and energy storage systems (RS-172060)
  • Development and Application of Methods and Materials for Monitoring New Organic Contaminants, Toxic Compounds and Heavy Metals (RS-172007)

DOI: 10.20964/2016.07.48

ISSN: 1452-3981

WoS: 000384905600050

Scopus: 2-s2.0-84978138152
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1941
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