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dc.creatorPantelic, Nebojsa
dc.creatorZmejkovski, Bojana
dc.creatorMarkovic, Dragana D
dc.creatorVujic, Jelena M
dc.creatorStanojković, Tatjana
dc.creatorSabo, Tibor
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2019-01-30T17:50:06Z
dc.date.available2019-01-30T17:50:06Z
dc.date.issued2016
dc.identifier.issn2075-4701
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1938
dc.description.abstractA novel gold(III) complex, [AuCl2{(S,S)-Et(2)eddl}]PF6, ((S,S)-Et(2)eddl = O,O-diethyl ester of ethylenediamine-N,N-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (H-1 and C-13), and 2D (H,H-COSY and H,H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R,R)-N,N diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S,S)-H(2)Et(2)eddl]Cl-2 and corresponding gold(III) complex was determined against tumor cell lines: human adenocarcinoma (HeLa), human colon carcinoma (LS174), human breast cancer (MCF7), non-small cell lung carcinoma cell line (A549), and non-cancerous cell line human embryonic lung fibroblast (MRC-5) using microculture tetrazolium test (MTT) assay. The results indicate that both ligand precursor and gold(III) complex have showed very good to moderate cytotoxic activity against all tested malignant cell lines. The highest activity was expressed by [AuCl2{(S,S)-Et(2)eddl}]PF6 against the LS174 cells, with IC50 value of 7.4 +/- 1.2 mu M.en
dc.publisherMdpi Ag, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.sourceMetals
dc.subjectgold(III) complexen
dc.subjectR(2)edda-type liganden
dc.subjectDFTen
dc.subjectcytotoxicityen
dc.titleSynthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Aciden
dc.typearticle
dc.rights.licenseBY
dcterms.abstractПантелиц, Небојса; Калудеровиц, Горан Н; Станојковиц, Татјана П; Змејковски, Бојана; Сабо, Тибор Ј; Вујиц, Јелена М; Марковиц, Драгана Д;
dc.citation.volume6
dc.citation.issue9
dc.citation.other6(9):
dc.citation.rankM21
dc.identifier.doi10.3390/met6090226
dc.identifier.rcubConv_3605
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8369/1936.pdf
dc.identifier.scopus2-s2.0-85006722238
dc.identifier.wos000385527100033
dc.type.versionpublishedVersion


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