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dc.creatorMarković, Vladimir M.
dc.creatorČupić, Željko
dc.creatorMacesic, Stevan
dc.creatorStanojevic, Ana
dc.creatorVukojevic, Vladana
dc.creatorKolar-Anić, Ljiljana
dc.date.accessioned2019-01-30T17:49:53Z
dc.date.available2019-01-30T17:49:53Z
dc.date.issued2016
dc.identifier.issn1477-8599
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1929
dc.description.abstractA mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory mechanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.en
dc.publisherOxford Univ Press, Oxford
dc.relationKarolinska Institute Research Funds
dc.relationSwedish Research Council
dc.relationKnut and Alice Wallenberg Foundation
dc.relationRajko and Maj Dermanovic Fund
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.rightsopenAccess
dc.sourceMathematical Medicine and Biology-A Journal of the Ima
dc.subjecthypothalamic-pituitary-adrenal (HPA) axisen
dc.subjectcholesterolen
dc.subjectcircadian and ultradian rhythmsen
dc.subjectcortisolen
dc.subjectdynamical diseasesen
dc.subjectstoichiometric network analysisen
dc.titleModelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарковиц, Владимир М; Чупић, Жељко; Вукојевиц, Владана; Мацесиц, Стеван; Колар-Aниц, Љиљана; Станојевиц, Aна;
dc.citation.volume33
dc.citation.issue1
dc.citation.spage1
dc.citation.epage28
dc.citation.other33(1): 1-28
dc.citation.rankM22
dc.identifier.pmid25332212
dc.identifier.doi10.1093/imammb/dqu020
dc.identifier.rcubConv_3518
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8359/1927.pdf
dc.identifier.scopus2-s2.0-84963762537
dc.identifier.wos000374232600001
dc.type.versionpublishedVersion


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