CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis

Thumbnail
2016
1927.pdf (1.124Mb)
Authors
Marković, Vladimir M.
Čupić, Željko
Macesic, Stevan
Stanojevic, Ana
Vukojevic, Vladana
Kolar-Anić, Ljiljana
Article (Published version)
Metadata
Show full item record
Abstract
A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory me...chanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.

Keywords:
hypothalamic-pituitary-adrenal (HPA) axis / cholesterol / circadian and ultradian rhythms / cortisol / dynamical diseases / stoichiometric network analysis
Source:
Mathematical Medicine and Biology-A Journal of the Ima, 2016, 33, 1, 1-28
Publisher:
  • Oxford Univ Press, Oxford
Funding / projects:
  • Karolinska Institute Research Funds
  • Swedish Research Council
  • Knut and Alice Wallenberg Foundation
  • Rajko and Maj Dermanovic Fund
  • Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
  • Nanostructured Functional and Composite Materials in Catalytic and Sorption Processes (RS-45001)

DOI: 10.1093/imammb/dqu020

ISSN: 1477-8599

PubMed: 25332212

WoS: 000374232600001

Scopus: 2-s2.0-84963762537
[ Google Scholar ]
20
15
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1929
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Marković, Vladimir M.
AU  - Čupić, Željko
AU  - Macesic, Stevan
AU  - Stanojevic, Ana
AU  - Vukojevic, Vladana
AU  - Kolar-Anić, Ljiljana
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1929
AB  - A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory mechanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.
PB  - Oxford Univ Press, Oxford
T2  - Mathematical Medicine and Biology-A Journal of the Ima
T1  - Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis
VL  - 33
IS  - 1
SP  - 1
EP  - 28
DO  - 10.1093/imammb/dqu020
ER  - 
@article{
author = "Marković, Vladimir M. and Čupić, Željko and Macesic, Stevan and Stanojevic, Ana and Vukojevic, Vladana and Kolar-Anić, Ljiljana",
year = "2016",
abstract = "A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory mechanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.",
publisher = "Oxford Univ Press, Oxford",
journal = "Mathematical Medicine and Biology-A Journal of the Ima",
title = "Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis",
volume = "33",
number = "1",
pages = "1-28",
doi = "10.1093/imammb/dqu020"
}
Marković, V. M., Čupić, Ž., Macesic, S., Stanojevic, A., Vukojevic, V.,& Kolar-Anić, L.. (2016). Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis. in Mathematical Medicine and Biology-A Journal of the Ima
Oxford Univ Press, Oxford., 33(1), 1-28.
https://doi.org/10.1093/imammb/dqu020
Marković VM, Čupić Ž, Macesic S, Stanojevic A, Vukojevic V, Kolar-Anić L. Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis. in Mathematical Medicine and Biology-A Journal of the Ima. 2016;33(1):1-28.
doi:10.1093/imammb/dqu020 .
Marković, Vladimir M., Čupić, Željko, Macesic, Stevan, Stanojevic, Ana, Vukojevic, Vladana, Kolar-Anić, Ljiljana, "Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis" in Mathematical Medicine and Biology-A Journal of the Ima, 33, no. 1 (2016):1-28,
https://doi.org/10.1093/imammb/dqu020 . .

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB