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dc.creatorYongabi, Kenneth Anchang
dc.creatorNovaković, Miroslav
dc.creatorBukvicki, Danka
dc.creatorReeb, Catherine
dc.creatorAsakawa, Yoshinori
dc.date.accessioned2019-01-30T17:49:51Z
dc.date.available2019-01-30T17:49:51Z
dc.date.issued2016
dc.identifier.issn1934-578X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1926
dc.description.abstractDiabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread problem of bacterial resistance to most commonly used antibiotics places a huge economic burden on the healthcare system, with both increased morbidity and mortality among diabetic patients with foot infections. In this study, the antibacterial activity of organic extracts of the fresh liverwort Marchantia debilis from the North West Region of Cameroon is reported. An exit pool system, where patients presenting with DBFIs consented to be involved in the use of phytomedicines, after long term treatment of ulcers with antibiotics and not yielding significant long term benefit, presented themselves at the Phytobiotechnology Research clinic (PRF). Continuous culture of swabs from foot and toe wounds from 30 infected patients on nutrient agar and MacConkey agars in triplicate as well as Gram stain microscopy, revealed the presence of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Bacillus species. Light petroleum and methanol extracts of the whole bryophyte plants at 100% concentration were tested. In vitro inhibition of the tested bacterial isolates from the diabetic foot ulcers by M debilis was observed only with the light petroleum extract. No inhibition by the extracts was observed for the Pseudomonas aeruginosa isolate. The light petroleum extract of M debilis was formulated into a petroleum oil based cream named BryoCream (TM). This was administered to 20 of the patients with 90% cure rate in a three week time period. The main nonpolar components were determined by GCMS as lepidozene and beta-barbatene, and by NMR. as stigmasterol and beta-sitosterol. In conclusion, nonpolar extracts from bryophytes from Cameroon could, potentially, be used to treat diabetic bacterial foot infections.en
dc.publisherNatural Products Inc, Westerville
dc.relationPhytobiotechnology Research Foundation of Cameroon
dc.relationMatsumae International Foundation
dc.rightsopenAccess
dc.sourceNatural Product Communications
dc.subjectMarchantia debilisen
dc.subjectLiverworten
dc.subjectDiabeticen
dc.subjectFooten
dc.subjectBacteriaen
dc.subjectInfectionen
dc.titleManagement of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroonen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAсакаwа, Yосхинори; Новаковић, Мирослав; Рееб, Цатхерине; Буквицки, Данка; Yонгаби, Кеннетх Aнцханг;
dc.citation.volume11
dc.citation.issue9
dc.citation.spage1333
dc.citation.epage1336
dc.citation.other11(9): 1333-1336
dc.citation.rankM23
dc.identifier.rcubConv_3596
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14697/1934578x1601100938.pdf
dc.identifier.wos000384513600038
dc.type.versionpublishedVersion


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