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Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1

Authorized Users Only
2016
Authors
Mileski, Ksenija S
Ciric, Ana D
Trifunović, Snežana
Ristic, Mihailo S
Soković, Marina
Matevski, Vlado S
Tešević, Vele
Jadranin, Milka
Marin, Petar D.
Dzamic, Ana M
Article (Published version)
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Abstract
GC-FID and GC-MS were used to determine the chemical composition of the essential oil of the aerial parts of Heracleum orphanidis Boiss. Also, the HPLC-DAD/ESI-ToF-MS profile of the methanol extracts of aerial parts and roots was determined. The main components of the essential oil were n-octanol, octyl hexanoate and n-octyl acetate, while coumarins were the most prevalent compounds in methanol extracts. An evaluation of antioxidant activity showed that the methanol and aqueous extracts of the aerial parts had the highest potential. In terms of antimicrobial activity determined by microdilution assays, the essential oil and methanol extract of the roots showed the greatest effectiveness. The colonies of Pseudomonas aeruginosa PAO1 treated with H. orphanidis samples produced less toxic pyocyanin, showed lower twitching and flagella mobility and biofilm formatting was reduced. The analyses in this study showed the considerable biological potential of H. orphanidis considering free radica...ls and various pathogenic strains, including the wild type of P. aeruginosa.

Source:
Food & Function, 2016, 7, 9, 4061-4074
Publisher:
  • Royal Soc Chemistry, Cambridge
Projects:
  • Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects (RS-173029)
  • Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
Note:
  • The peer-reviewed version: http://cer.ihtm.bg.ac.rs/handle/123456789/3130

DOI: 10.1039/c6fo01018k

ISSN: 2042-6496

PubMed: 27713984

WoS: 000384254100041

Scopus: 2-s2.0-84987888552
[ Google Scholar ]
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1923
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