The noise due to stochastic fluctuations of the number of adsorbed analyte particles, caused by random adsorption-desorption (AD) process coupled with analyte convection and diffusion, is inherent to adsorption-based bio/chemical sensors. It posses the fundamental limit for the detection of analyte. In this study we perform an analysis of the signal-to-noise ratio (SNR) of microfluidic sensors, taking into account their AD noise. We have shown that mass transfer significantly influences the possibility to achieve the acceptable SNR value. It also influences the minimal detectable concentration and also the time necessary to reach the SNR value that ensures reliable real-time detection and quantification of the analyte.
Keywords:
signal-to-noise ratio / microfluidic sensor / biosensor
Source:
Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016, 2016, 168, 642-645
TY - CONF
AU - Đurić, Zoran G.
AU - Jokić, Ivana
AU - Milovanovic, G.
PY - 2016
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1910
AB - The noise due to stochastic fluctuations of the number of adsorbed analyte particles, caused by random adsorption-desorption (AD) process coupled with analyte convection and diffusion, is inherent to adsorption-based bio/chemical sensors. It posses the fundamental limit for the detection of analyte. In this study we perform an analysis of the signal-to-noise ratio (SNR) of microfluidic sensors, taking into account their AD noise. We have shown that mass transfer significantly influences the possibility to achieve the acceptable SNR value. It also influences the minimal detectable concentration and also the time necessary to reach the SNR value that ensures reliable real-time detection and quantification of the analyte.
PB - Elsevier
C3 - Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016
T1 - Signal-to-Noise Ratio in Adsorption-Based Microfluidic Bio/Chemical Sensors
VL - 168
SP - 642
EP - 645
DO - 10.1016/j.proeng.2016.11.234
ER -
@conference{
author = "Đurić, Zoran G. and Jokić, Ivana and Milovanovic, G.",
year = "2016",
abstract = "The noise due to stochastic fluctuations of the number of adsorbed analyte particles, caused by random adsorption-desorption (AD) process coupled with analyte convection and diffusion, is inherent to adsorption-based bio/chemical sensors. It posses the fundamental limit for the detection of analyte. In this study we perform an analysis of the signal-to-noise ratio (SNR) of microfluidic sensors, taking into account their AD noise. We have shown that mass transfer significantly influences the possibility to achieve the acceptable SNR value. It also influences the minimal detectable concentration and also the time necessary to reach the SNR value that ensures reliable real-time detection and quantification of the analyte.",
publisher = "Elsevier",
journal = "Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016",
title = "Signal-to-Noise Ratio in Adsorption-Based Microfluidic Bio/Chemical Sensors",
volume = "168",
pages = "642-645",
doi = "10.1016/j.proeng.2016.11.234"
}
Đurić, Z. G., Jokić, I.,& Milovanovic, G.. (2016). Signal-to-Noise Ratio in Adsorption-Based Microfluidic Bio/Chemical Sensors. in Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016
Elsevier., 168, 642-645.
https://doi.org/10.1016/j.proeng.2016.11.234
Đurić ZG, Jokić I, Milovanovic G. Signal-to-Noise Ratio in Adsorption-Based Microfluidic Bio/Chemical Sensors. in Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016. 2016;168:642-645.
doi:10.1016/j.proeng.2016.11.234 .
Đurić, Zoran G., Jokić, Ivana, Milovanovic, G., "Signal-to-Noise Ratio in Adsorption-Based Microfluidic Bio/Chemical Sensors" in Proceedings of the 30th Anniversary Eurosensors Conference - Eurosensors 2016, 168 (2016):642-645,
https://doi.org/10.1016/j.proeng.2016.11.234 . .
