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Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa

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2016
1934578x1601101232.pdf (419.6Kb)
Authors
Bukvicki, Danka
Ciric, Ana
Soković, Marina
Vannini, Lucia
Nissen, Lorenzo
Novaković, Miroslav
Vujisić, Ljubodrag V.
Asakawa, Yoshinori
Marin, Petar D.
Article (Published version)
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Abstract
The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was tested against six bacterial and seven fungal strains and high antimicrobial potential was noticed. Minimum inhibitory concentration varied from 0.031 mg/mL to 0.5 mg/mL for bacterial and 0.062 mg/mL to 0.5 mg/mL for fungal strains. The antiquorum properties of the essential oil were evaluated on Pseudomonas aeruginosa PAO1. The oil was tested at subMiC concentrations for anti-quorum sensing activity. The analyses on quorum-sensing functions have been carried out by evaluating twitching and swarming of bacterial cultures and the total amount of pyocyanin production produced by P. aeruginosa. This study showed that M thymifolia essential oil exhib...ited antiquorum sensing activity and may be used as an antipathogenic drug.

Keywords:
Micromeria thymifolia / Essential oil / Antimicrobial activity / Antiquorum effect / GC-MS
Source:
Natural Product Communications, 2016, 11, 12, 1903-1906
Publisher:
  • Natural Products Inc, Westerville
Projects:
  • Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects (RS-173029)
  • Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Department of Agricultural and Food Sciences, University of Bologna, Italy

ISSN: 1934-578X

PubMed: 30508362

WoS: 000390975600032

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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1906
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