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Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode

Authorized Users Only
2016
Authors
Lović, Jelena
Trišović, Nemanja
Antanasijevic, Jelena
Nikolić, Nebojša D.
Stevanović, Sanja
Mijin, Dušan
Vukovic, Dragan
Mladenović, Aleksandar R.
Petrović, Slobodan D.
Avramov Ivić, Milka
Article (Published version)
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Abstract
Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC...-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.

Keywords:
Sildenafil citrate / Au/Cys electrode / Human serum analysis / Surface microscopic analysis
Source:
Journal of Electroanalytical Chemistry, 2016, 782, 103-107
Publisher:
  • Elsevier
Projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
  • New approach in designing materials for energy conversion and energy storage systems (RS-172060)

DOI: 10.1016/j.jelechem.2016.10.022

ISSN: 1572-6657

WoS: 000390510000015

Scopus: 2-s2.0-84992195164
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1902
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