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dc.creatorEdeler, David
dc.creatorKaluderovic, Milena R.
dc.creatorDojčinović, Biljana
dc.creatorSchmidt, Harry
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2019-01-30T17:49:13Z
dc.date.available2019-01-30T17:49:13Z
dc.date.issued2016
dc.identifier.issn2046-2069
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1896
dc.description.abstractThe anticancer drug cisplatin (CP) is loaded into SBA-15 mesoporous silica (SBA-15 vertical bar CP) and its release from the nanomaterial is studied. The CP-loaded SBA-15 is tested against four tumor cell lines: mouse malignant melanoma B16F10, human adenocarcinoma HeLa, colon HT-29 and prostate PC3. Most importantly, the superiority of this novel material in comparison to CP arises from the fact that the CP-grafted nanomaterial SBA-15 (-> SBA-15 vertical bar CP) is enhancing cessation of proliferation along with induction of senescence in B16F10 in approximately 3.5 times lower concentration. The control material loaded with therapeutically inactive K-2[PtCl4] (-> SBA-15 vertical bar TC) showed no antitumor activity. To a large extent, SBA15| CP-induced senescence might present a safe approach in tumor treatment. Such cells can be cleared by immune cells resulting in efficient tumor regression. So far only apoptotic agents are being exploited in clinics, thus an understanding of the chemotherapeutic-induced senescence will allow oncologists to explore this essential tumor suppressor mechanism.en
dc.publisherThe Royal Society of Chemistry
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRSC Advances
dc.titleSBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cellsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractСцхмидт, Харрy; Дојчиновић, Биљана; Калудеровиц, Милена Р.; Калудеровиц, Горан Н.; Еделер, Давид;
dc.citation.volume6
dc.citation.issue112
dc.citation.spage111031
dc.citation.epage111040
dc.citation.other6(112): 111031-111040
dc.citation.rankM22
dc.identifier.doi10.1039/c6ra22596a
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs//bitstream/id/8333/1894.pdf
dc.identifier.scopus2-s2.0-84997482111
dc.identifier.wos000389463600062
dc.type.versionpublishedVersion


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