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SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells

Thumbnail
2016
1894.pdf (1.158Mb)
Authors
Edeler, David
Kaluderovic, Milena R.
Dojčinović, Biljana
Schmidt, Harry
Kaluđerović, Goran N.
Article (Published version)
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Abstract
The anticancer drug cisplatin (CP) is loaded into SBA-15 mesoporous silica (SBA-15 vertical bar CP) and its release from the nanomaterial is studied. The CP-loaded SBA-15 is tested against four tumor cell lines: mouse malignant melanoma B16F10, human adenocarcinoma HeLa, colon HT-29 and prostate PC3. Most importantly, the superiority of this novel material in comparison to CP arises from the fact that the CP-grafted nanomaterial SBA-15 (-> SBA-15 vertical bar CP) is enhancing cessation of proliferation along with induction of senescence in B16F10 in approximately 3.5 times lower concentration. The control material loaded with therapeutically inactive K-2[PtCl4] (-> SBA-15 vertical bar TC) showed no antitumor activity. To a large extent, SBA15| CP-induced senescence might present a safe approach in tumor treatment. Such cells can be cleared by immune cells resulting in efficient tumor regression. So far only apoptotic agents are being exploited in clinics, thus an understanding of the c...hemotherapeutic-induced senescence will allow oncologists to explore this essential tumor suppressor mechanism.

Source:
RSC Advances, 2016, 6, 112, 111031-111040
Publisher:
  • The Royal Society of Chemistry

DOI: 10.1039/c6ra22596a

ISSN: 2046-2069

WoS: 000389463600062

Scopus: 2-s2.0-84997482111
[ Google Scholar ]
21
17
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1896
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Edeler, David
AU  - Kaluderovic, Milena R.
AU  - Dojčinović, Biljana
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1896
AB  - The anticancer drug cisplatin (CP) is loaded into SBA-15 mesoporous silica (SBA-15 vertical bar CP) and its release from the nanomaterial is studied. The CP-loaded SBA-15 is tested against four tumor cell lines: mouse malignant melanoma B16F10, human adenocarcinoma HeLa, colon HT-29 and prostate PC3. Most importantly, the superiority of this novel material in comparison to CP arises from the fact that the CP-grafted nanomaterial SBA-15 (-> SBA-15 vertical bar CP) is enhancing cessation of proliferation along with induction of senescence in B16F10 in approximately 3.5 times lower concentration. The control material loaded with therapeutically inactive K-2[PtCl4] (-> SBA-15 vertical bar TC) showed no antitumor activity. To a large extent, SBA15| CP-induced senescence might present a safe approach in tumor treatment. Such cells can be cleared by immune cells resulting in efficient tumor regression. So far only apoptotic agents are being exploited in clinics, thus an understanding of the chemotherapeutic-induced senescence will allow oncologists to explore this essential tumor suppressor mechanism.
PB  - The Royal Society of Chemistry
T2  - RSC Advances
T1  - SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells
VL  - 6
IS  - 112
SP  - 111031
EP  - 111040
DO  - 10.1039/c6ra22596a
ER  - 
@article{
author = "Edeler, David and Kaluderovic, Milena R. and Dojčinović, Biljana and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2016",
abstract = "The anticancer drug cisplatin (CP) is loaded into SBA-15 mesoporous silica (SBA-15 vertical bar CP) and its release from the nanomaterial is studied. The CP-loaded SBA-15 is tested against four tumor cell lines: mouse malignant melanoma B16F10, human adenocarcinoma HeLa, colon HT-29 and prostate PC3. Most importantly, the superiority of this novel material in comparison to CP arises from the fact that the CP-grafted nanomaterial SBA-15 (-> SBA-15 vertical bar CP) is enhancing cessation of proliferation along with induction of senescence in B16F10 in approximately 3.5 times lower concentration. The control material loaded with therapeutically inactive K-2[PtCl4] (-> SBA-15 vertical bar TC) showed no antitumor activity. To a large extent, SBA15| CP-induced senescence might present a safe approach in tumor treatment. Such cells can be cleared by immune cells resulting in efficient tumor regression. So far only apoptotic agents are being exploited in clinics, thus an understanding of the chemotherapeutic-induced senescence will allow oncologists to explore this essential tumor suppressor mechanism.",
publisher = "The Royal Society of Chemistry",
journal = "RSC Advances",
title = "SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells",
volume = "6",
number = "112",
pages = "111031-111040",
doi = "10.1039/c6ra22596a"
}
Edeler, D., Kaluderovic, M. R., Dojčinović, B., Schmidt, H.,& Kaluđerović, G. N.. (2016). SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells. in RSC Advances
The Royal Society of Chemistry., 6(112), 111031-111040.
https://doi.org/10.1039/c6ra22596a
Edeler D, Kaluderovic MR, Dojčinović B, Schmidt H, Kaluđerović GN. SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells. in RSC Advances. 2016;6(112):111031-111040.
doi:10.1039/c6ra22596a .
Edeler, David, Kaluderovic, Milena R., Dojčinović, Biljana, Schmidt, Harry, Kaluđerović, Goran N., "SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells" in RSC Advances, 6, no. 112 (2016):111031-111040,
https://doi.org/10.1039/c6ra22596a . .

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