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dc.creatorBožić, Aleksandra R.
dc.creatorMarinković, Aleksandar D.
dc.creatorBjelogrlić, Snežana K.
dc.creatorTodorović, Tamara
dc.creatorCvijetić, Ilija
dc.creatorNovaković, Irena
dc.creatorMuller, Christian D.
dc.creatorFilipovic, Nenad R.
dc.date.accessioned2019-01-30T17:49:12Z
dc.date.available2019-01-30T17:49:12Z
dc.date.issued2016
dc.identifier.issn2046-2069
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1895
dc.description.abstractA comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationCOST Action CM1106 StemChem - "Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells"
dc.rightsopenAccess
dc.sourceRSC Advances
dc.titleQuinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell modelsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractФилиповиц, Ненад Р.; Бјелогрлић, Снежана К.; Маринковиц, Aлександар; Новаковић, Ирена; Бозиц, Aлександра; Цвијетић, Илија Н.; Тодоровиц, Тамара Р.; Муллер, Цхристиан Д.;
dc.citation.volume6
dc.citation.issue106
dc.citation.spage104763
dc.citation.epage104781
dc.citation.other6(106): 104763-104781
dc.citation.rankM22
dc.identifier.doi10.1039/c6ra23940d
dc.identifier.rcubConv_3627
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8332/1893.pdf
dc.identifier.scopus2-s2.0-84994477669
dc.identifier.wos000388111900107
dc.type.versionpublishedVersion


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