Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species

2016
Authors
Dmitrović, Slavica
Škorić, Marijana

Boljević, Jelena

Aničić, Neda

Božić, Dragana

Mišić, Danijela

Filipović, Vuk

Opsenica, Dejan

Article (Published version)
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The presented study aimed to investigate the elicitation possibility for the production of main secondary metabolites in Nepeta cataria L. and N. pannonica L. plants, by exposing them to synthetic compounds belonging to tetraoxanes and thiophenes group. The effect of DO63 (1,2,4,5-tetraoxane) and DOVF15 (2,5-diphenylthiophene) on the production of cis-trans-nepetalactone (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in shoots grown on the culture medium with the addition of synthetic compounds in the concentrations ranging from 0.1 to 2 mg L-1. The content of targeted metabolites in tested in vitro shoots depended on the type and concentration of applied synthetic compounds. Application of DO63 in the concentration range 0.1-1 mg L-1 affected only NL production in both Nepeta species resulting in its increased content, while production of RA was not influenced in the treated shoots. Addition of DOVF15 caused decreased RA content in N. pannonica shoots and an inc...rease in N. cataria shoots, whereas NL production was not affected. The presented results reveal the possibility of DO63 and DOVF15 application for the elicitation of the main secondary metabolites production in species from the genus Nepeta.
Keywords:
1,2,4,5-tetraoxanes / 2,5-diphenylthiophenes / cis-trans-nepetalactone / rosmarinic acid / Nepeta cataria / Nepeta pannonicaSource:
Journal of the Serbian Chemical Society, 2016, 81, 9, 999-1012Publisher:
- Serbian Chemical Society
Funding / projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Physiological, chemical and molecular analysis of the diversity of selected rare and endangered plant species and application of biotechnology for ex situ conservation and production of biologically active compounds (RS-173024)
DOI: 10.2298/JSC160226054D
ISSN: 0352-5139
WoS: 000388027500003
Scopus: 2-s2.0-84994005249
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IHTMTY - JOUR AU - Dmitrović, Slavica AU - Škorić, Marijana AU - Boljević, Jelena AU - Aničić, Neda AU - Božić, Dragana AU - Mišić, Danijela AU - Filipović, Vuk AU - Opsenica, Dejan PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1892 AB - The presented study aimed to investigate the elicitation possibility for the production of main secondary metabolites in Nepeta cataria L. and N. pannonica L. plants, by exposing them to synthetic compounds belonging to tetraoxanes and thiophenes group. The effect of DO63 (1,2,4,5-tetraoxane) and DOVF15 (2,5-diphenylthiophene) on the production of cis-trans-nepetalactone (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in shoots grown on the culture medium with the addition of synthetic compounds in the concentrations ranging from 0.1 to 2 mg L-1. The content of targeted metabolites in tested in vitro shoots depended on the type and concentration of applied synthetic compounds. Application of DO63 in the concentration range 0.1-1 mg L-1 affected only NL production in both Nepeta species resulting in its increased content, while production of RA was not influenced in the treated shoots. Addition of DOVF15 caused decreased RA content in N. pannonica shoots and an increase in N. cataria shoots, whereas NL production was not affected. The presented results reveal the possibility of DO63 and DOVF15 application for the elicitation of the main secondary metabolites production in species from the genus Nepeta. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species VL - 81 IS - 9 SP - 999 EP - 1012 DO - 10.2298/JSC160226054D ER -
@article{ author = "Dmitrović, Slavica and Škorić, Marijana and Boljević, Jelena and Aničić, Neda and Božić, Dragana and Mišić, Danijela and Filipović, Vuk and Opsenica, Dejan", year = "2016", abstract = "The presented study aimed to investigate the elicitation possibility for the production of main secondary metabolites in Nepeta cataria L. and N. pannonica L. plants, by exposing them to synthetic compounds belonging to tetraoxanes and thiophenes group. The effect of DO63 (1,2,4,5-tetraoxane) and DOVF15 (2,5-diphenylthiophene) on the production of cis-trans-nepetalactone (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in shoots grown on the culture medium with the addition of synthetic compounds in the concentrations ranging from 0.1 to 2 mg L-1. The content of targeted metabolites in tested in vitro shoots depended on the type and concentration of applied synthetic compounds. Application of DO63 in the concentration range 0.1-1 mg L-1 affected only NL production in both Nepeta species resulting in its increased content, while production of RA was not influenced in the treated shoots. Addition of DOVF15 caused decreased RA content in N. pannonica shoots and an increase in N. cataria shoots, whereas NL production was not affected. The presented results reveal the possibility of DO63 and DOVF15 application for the elicitation of the main secondary metabolites production in species from the genus Nepeta.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species", volume = "81", number = "9", pages = "999-1012", doi = "10.2298/JSC160226054D" }
Dmitrović, S., Škorić, M., Boljević, J., Aničić, N., Božić, D., Mišić, D., Filipović, V.,& Opsenica, D.. (2016). Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species. in Journal of the Serbian Chemical Society Serbian Chemical Society., 81(9), 999-1012. https://doi.org/10.2298/JSC160226054D
Dmitrović S, Škorić M, Boljević J, Aničić N, Božić D, Mišić D, Filipović V, Opsenica D. Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species. in Journal of the Serbian Chemical Society. 2016;81(9):999-1012. doi:10.2298/JSC160226054D .
Dmitrović, Slavica, Škorić, Marijana, Boljević, Jelena, Aničić, Neda, Božić, Dragana, Mišić, Danijela, Filipović, Vuk, Opsenica, Dejan, "Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species" in Journal of the Serbian Chemical Society, 81, no. 9 (2016):999-1012, https://doi.org/10.2298/JSC160226054D . .