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dc.creatorTrifunovic-Macedoljan, Jelena
dc.creatorPantelić, Nebojša Đ.
dc.creatorDamjanovic, Ana
dc.creatorRaskovic, Sanvila
dc.creatorNikolic-Durovic, Marina
dc.creatorPudar, Georgina
dc.creatorJadranin, Milka
dc.creatorJuranić, Ivan
dc.creatorJuranić, Zorica
dc.date.accessioned2019-01-30T17:48:37Z
dc.date.available2019-01-30T17:48:37Z
dc.date.issued2016
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1865
dc.description.abstractBiogenic amines are integral part of nearly every cell. In the present study, the method of acidic extraction of histamine (His), of polyamines putrescine (Put), spermidine (Spd) and catecholamines epinephrine (Epi) and norepinephrine (NE) from human serum, precolumn derivatization with dansyl chloride, and LC/DAD analysis of the biogenic amines was used with the aim of monitoring differences of their levels in patients with diabetes mellitus, chronic urticaria, and Hashimoto's thyroiditis, compared to healthy subjects, and to observe them as possible markers for immune mediated diseases. The retention times were used for the determination of serum biogenic amines. Statistically significant differences were found in the levels of putrescine and histamine in diabetes mellitus patients, of the levels of putrescine, histamine, spermidine and epinephrine in chronic urticaria patients and of the levels of putrescine and spermidine levels in Hashimoto's thyroiditis patients, compared to those of healthy controls. Norepinephrine was found only in the serum of patients with chronic urticaria. The values of recovery, evaluated in controls, varied between 85.7 and 106.7 %. The statistically significant changes in putrescine, histamine, spermidine and epinephrine levels in patients compared with those in healthy people reflects the existence of biochemical disturbances in the mentioned immune-mediated diseases.en
dc.publisherSerbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectbiogenic aminesen
dc.subjectserumen
dc.subjectimmune-mediated diseasesen
dc.subjectmarkersen
dc.subjectLC/DADen
dc.titleLC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditisen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractТрифуновиц-Мацедољан, Јелена; Дамјановиц, Aна; Јураниц, Зорица; Расковиц, Санвила; Николиц-Дуровиц, Марина; Пудар, Георгина; Јадранин, Милка; Јураниц, Иван; Пантелиц, Небојса;
dc.citation.volume81
dc.citation.issue5
dc.citation.spage487
dc.citation.epage498
dc.citation.other81(5): 487-498
dc.citation.rankM23
dc.identifier.doi10.2298/JSC150910020T
dc.identifier.rcubConv_3560
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8302/1863.pdf
dc.identifier.scopus2-s2.0-84978289286
dc.identifier.wos000379232800002
dc.type.versionpublishedVersion


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