A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations
Abstract
In adsorption-based chemical and biological refractometric sensors the dependence of the refractive index of the sensing area on the number of adsorbed particles is used for detection and quantification of analytes. We perform stochastic analysis of equilibrium fluctuations of the adsorbed particles number for monolayer adsorption using a nonlinear second-order model. We derive an analytical expression for the power spectral density (PSD) of the refractive index change fluctuations. Our theory is applicable to sensors operating in closed volume systems with spatially uniform analyte concentration. Our analysis of fluctuations in a benzene sensor shows a significant difference between the PSD according to the derived expression and the PSD obtained by the linear adsorption model, especially for very low amounts of analyte. The developed theory is valid in a wider range of pressures and temperatures. Since signal fluctuations determine the detection limit, the presented theoretical model... is applicable as a tool for the design, optimization and characterization of practical adsorption-based refractometric sensors.
Keywords:
Adsorption-desorption noise / Equilibrium fluctuations / Plasmonic sensor / Stochastic analysisSource:
Optical and Quantum Electronics, 2016, 48, 7Publisher:
- Springer, Dordrecht
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
DOI: 10.1007/s11082-016-0620-0
ISSN: 0306-8919
WoS: 000379174800009
Scopus: 2-s2.0-84975744268
Collections
Institution/Community
IHTMTY - JOUR AU - Jokić, Ivana AU - Jakšić, Olga PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1856 AB - In adsorption-based chemical and biological refractometric sensors the dependence of the refractive index of the sensing area on the number of adsorbed particles is used for detection and quantification of analytes. We perform stochastic analysis of equilibrium fluctuations of the adsorbed particles number for monolayer adsorption using a nonlinear second-order model. We derive an analytical expression for the power spectral density (PSD) of the refractive index change fluctuations. Our theory is applicable to sensors operating in closed volume systems with spatially uniform analyte concentration. Our analysis of fluctuations in a benzene sensor shows a significant difference between the PSD according to the derived expression and the PSD obtained by the linear adsorption model, especially for very low amounts of analyte. The developed theory is valid in a wider range of pressures and temperatures. Since signal fluctuations determine the detection limit, the presented theoretical model is applicable as a tool for the design, optimization and characterization of practical adsorption-based refractometric sensors. PB - Springer, Dordrecht T2 - Optical and Quantum Electronics T1 - A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations VL - 48 IS - 7 DO - 10.1007/s11082-016-0620-0 ER -
@article{ author = "Jokić, Ivana and Jakšić, Olga", year = "2016", abstract = "In adsorption-based chemical and biological refractometric sensors the dependence of the refractive index of the sensing area on the number of adsorbed particles is used for detection and quantification of analytes. We perform stochastic analysis of equilibrium fluctuations of the adsorbed particles number for monolayer adsorption using a nonlinear second-order model. We derive an analytical expression for the power spectral density (PSD) of the refractive index change fluctuations. Our theory is applicable to sensors operating in closed volume systems with spatially uniform analyte concentration. Our analysis of fluctuations in a benzene sensor shows a significant difference between the PSD according to the derived expression and the PSD obtained by the linear adsorption model, especially for very low amounts of analyte. The developed theory is valid in a wider range of pressures and temperatures. Since signal fluctuations determine the detection limit, the presented theoretical model is applicable as a tool for the design, optimization and characterization of practical adsorption-based refractometric sensors.", publisher = "Springer, Dordrecht", journal = "Optical and Quantum Electronics", title = "A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations", volume = "48", number = "7", doi = "10.1007/s11082-016-0620-0" }
Jokić, I.,& Jakšić, O.. (2016). A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations. in Optical and Quantum Electronics Springer, Dordrecht., 48(7). https://doi.org/10.1007/s11082-016-0620-0
Jokić I, Jakšić O. A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations. in Optical and Quantum Electronics. 2016;48(7). doi:10.1007/s11082-016-0620-0 .
Jokić, Ivana, Jakšić, Olga, "A second-order nonlinear model of monolayer adsorption in refractometric chemical sensors and biosensors case of equilibrium fluctuations" in Optical and Quantum Electronics, 48, no. 7 (2016), https://doi.org/10.1007/s11082-016-0620-0 . .