Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H
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2016
Authors
Vulović, Bojan
Kolarski, Dusan
Bihelović, Filip

Matović, Radomir

Gruden, Maja

Saičić, Radomir N.

Article (Published version)

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Show full item recordAbstract
1,6-Diynes with a t-butylcarbonate group in the propargylic position undergo gold(I)-catalyzed dominocyclization which affords alpha-hydroxycyclohexenones. The described sequence can be applied on functionalized, highly oxygenated substrates, as examplified in the synthesis of (-)-gabosine H and its epimer.
Source:
Organic Letters, 2016, 18, 15, 3886-3889Publisher:
- Amer Chemical Soc, Washington
Projects:
- The development of new synthetic methods and their application in the synthesis of natural products and biologically active molecules (RS-172027)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-256716)
- Serbian Academy of Sciences and Arts [F193]
DOI: 10.1021/acs.orglett.6b01898
ISSN: 1523-7060
PubMed: 27456978