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dc.creatorIsailovic, Tanja
dc.creatorDordevic, Sanela
dc.creatorMarković, Bojan D.
dc.creatorRanđelović, Danijela
dc.creatorCekic, Nebojsa
dc.creatorLukić, Milica
dc.creatorPantelić, Ivana
dc.creatorDaniels, Rolf
dc.creatorSavić, Snežana D.
dc.date.accessioned2019-01-30T17:48:12Z
dc.date.available2019-01-30T17:48:12Z
dc.date.issued2016
dc.identifier.issn0022-3549
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1846
dc.description.abstractWe aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectnanotechnologyen
dc.subjectsucrose estersen
dc.subjectphospholipidsen
dc.subjectsolubilityen
dc.subjectexperimental designen
dc.subjectphysicochemical propertiesen
dc.subjectdrug-excipient interactionen
dc.subjectphysical stabilityen
dc.subjecttape strippingen
dc.subjectskin irritation potentialen
dc.titleBiocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Designen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИсаиловиц, Тања; Даниелс, Ролф; Цекиц, Небојса; Ранђеловић, Данијела; Дордевиц, Санела; Марковиц, Бојан; Лукиц, Милица; Пантелиц, Ивана; Савиц, Снезана;
dc.citation.volume105
dc.citation.issue1
dc.citation.spage308
dc.citation.epage323
dc.citation.other105(1): 308-323
dc.citation.rankM22
dc.identifier.pmid26539935
dc.identifier.doi10.1002/jps.24706
dc.identifier.rcubConv_3581
dc.identifier.scopus2-s2.0-84964478863
dc.identifier.wos000381768000038
dc.type.versionpublishedVersion


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