Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design
Samo za registrovane korisnike
2016
Autori
Isailovic, TanjaDordevic, Sanela
Marković, Bojan D.
Randjelović, Danijela
Cekic, Nebojsa
Lukić, Milica
Pantelić, Ivana
Daniels, Rolf
Savić, Snežana D.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degr...ees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.
Ključne reči:
nanotechnology / sucrose esters / phospholipids / solubility / experimental design / physicochemical properties / drug-excipient interaction / physical stability / tape stripping / skin irritation potentialIzvor:
Journal of Pharmaceutical Sciences, 2016, 105, 1, 308-323Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-MESTD-Technological Development (TD or TR)-34031)
- Mikro, nano-sistemi i senzori za primenu u elektroprivredi, procesnoj industriji i zaštiti životne sredine (RS-MESTD-Technological Development (TD or TR)-32008)
DOI: 10.1002/jps.24706
ISSN: 0022-3549
PubMed: 26539935
WoS: 000381768000038
Scopus: 2-s2.0-84964478863
Institucija/grupa
IHTMTY - JOUR AU - Isailovic, Tanja AU - Dordevic, Sanela AU - Marković, Bojan D. AU - Randjelović, Danijela AU - Cekic, Nebojsa AU - Lukić, Milica AU - Pantelić, Ivana AU - Daniels, Rolf AU - Savić, Snežana D. PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1846 AB - We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances. PB - Wiley, Hoboken T2 - Journal of Pharmaceutical Sciences T1 - Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design VL - 105 IS - 1 SP - 308 EP - 323 DO - 10.1002/jps.24706 ER -
@article{ author = "Isailovic, Tanja and Dordevic, Sanela and Marković, Bojan D. and Randjelović, Danijela and Cekic, Nebojsa and Lukić, Milica and Pantelić, Ivana and Daniels, Rolf and Savić, Snežana D.", year = "2016", abstract = "We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.", publisher = "Wiley, Hoboken", journal = "Journal of Pharmaceutical Sciences", title = "Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design", volume = "105", number = "1", pages = "308-323", doi = "10.1002/jps.24706" }
Isailovic, T., Dordevic, S., Marković, B. D., Randjelović, D., Cekic, N., Lukić, M., Pantelić, I., Daniels, R.,& Savić, S. D.. (2016). Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design. in Journal of Pharmaceutical Sciences Wiley, Hoboken., 105(1), 308-323. https://doi.org/10.1002/jps.24706
Isailovic T, Dordevic S, Marković BD, Randjelović D, Cekic N, Lukić M, Pantelić I, Daniels R, Savić SD. Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design. in Journal of Pharmaceutical Sciences. 2016;105(1):308-323. doi:10.1002/jps.24706 .
Isailovic, Tanja, Dordevic, Sanela, Marković, Bojan D., Randjelović, Danijela, Cekic, Nebojsa, Lukić, Milica, Pantelić, Ivana, Daniels, Rolf, Savić, Snežana D., "Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design" in Journal of Pharmaceutical Sciences, 105, no. 1 (2016):308-323, https://doi.org/10.1002/jps.24706 . .