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dc.creatorFilipovic, Nenad R.
dc.creatorBjelogrlić, Snežana K.
dc.creatorMarinković, Aleksandar D.
dc.creatorVerbić, Tatjana
dc.creatorCvijetić, Ilija
dc.creatorSencanski, Milan
dc.creatorRodić, Marko V.
dc.creatorVujčić, Miroslava
dc.creatorSladić, Dušan
dc.creatorStrikovic, Zlatko
dc.creatorTodorović, Tamara
dc.creatorMuller, Christian D.
dc.date.accessioned2019-01-30T17:47:51Z
dc.date.available2019-01-30T17:47:51Z
dc.date.issued2015
dc.identifier.issn2046-2069
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1830
dc.description.abstractA new Zn(II)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(II) complex consists of a cation [Zn(Hqasesc)(2)](2+), two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(II) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(II) complex display cell phenotype specific activity.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171017/RS//
dc.relationEuropean Commission
dc.relationCOST Action CM1106 StemChem - "Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells"
dc.rightsopenAccess
dc.sourceRSC Advances
dc.titleZn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose inductionen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractМуллер, Цхристиан Д; Бјелогрлић, Снежана К.; Маринковиц, Aлександар; Филиповиц, Ненад Р; Цвијетић, Илија Н.; Стриковиц, Златко; Вујчић, Мирослава; Вербиц, Татјана З; Тодоровиц, Тамара Р; Сладиц, Дусан; Сенцански, Милан; Родић, Марко В.;
dc.citation.volume5
dc.citation.issue115
dc.citation.spage95191
dc.citation.epage95211
dc.citation.other5(115): 95191-95211
dc.citation.rankM21
dc.identifier.doi10.1039/c5ra19849f
dc.identifier.rcubConv_3445
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8271/1828.pdf
dc.identifier.scopus2-s2.0-84946944475
dc.identifier.wos000364906600078
dc.type.versionpublishedVersion


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