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dc.creatorŠukalović, Vladimir
dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.creatorKostić Rajačić, Slađana
dc.creatorSchrattenholz, A
dc.creatorŠoškić, Vukić
dc.date.accessioned2019-01-30T17:12:48Z
dc.date.available2019-01-30T17:12:48Z
dc.date.issued2005
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/182
dc.description.abstract5-[3-(4-Arylpiperazin-1-yl)propyl]-1H-benzimidazoles and 5-[2-(4-aryipiperazin-1-yl)ethoxy]-1H-benzimidazoles were synthesized and their affinity for the D-1, D-2 and 5-HT1A, receptors examined. They expressed a rather high affinity for the D-2 doparnine receptor. The main features of ligand-D-2 receptor interactions revealed by docking analyses were: salt bridge between piperazine ring protonated N-1 and Asp 86, hydrogen bonds of ligand bezimidazole part with Ser 141, Ser 122 and His 189, edge-to-face interactions of arylpiperazine aromatic ring with Phe 178, Tyr 216 and Trp 182 and hydrogen bond between ethereal oxygen in ethylenoxy ligands and hydrogen of Phe 185 or Trp 115. The most active 5-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethoxy}-1,3-di hydro-2H-benzimidazole-2-thione (27) has a maximal number of attractive interactions. A satisfactory correlation between docking of the compounds into the D-2 receptor and competition binding results was observed.en
dc.publisherEditions Scientifiques Medicales Elsevier, Paris
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectarylpiperazinesen
dc.subjectD2 receptoren
dc.subject5-HT1A receptoren
dc.subjectbinding pocketen
dc.subjectdocking analysisen
dc.titleSynthesis, dopamine D-2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl)propyl]-1H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1H-benzimidazole and their analogsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСцхраттенхолз, A; Соскиц, В; Костић Рајачић, Слађана; Роглиц, Г; Шукаловић, Владимир; Aндриц, Д;
dc.citation.volume40
dc.citation.issue5
dc.citation.spage481
dc.citation.epage493
dc.citation.other40(5): 481-493
dc.citation.rankM22
dc.identifier.pmid15893022
dc.identifier.doi10.1016/j.ejmech.2004.10.006
dc.identifier.rcubConv_2312
dc.identifier.scopus2-s2.0-18844409842
dc.identifier.wos000230243200007
dc.type.versionpublishedVersion


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