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dc.creatorTodosijević, Marija
dc.creatorSavić, Miroslav M.
dc.creatorBatinić, Bojan B.
dc.creatorMarković, Bojan D.
dc.creatorGasperlin, Mirjana
dc.creatorRandjelović, Danijela
dc.creatorLukić, Milica
dc.creatorSavić, Snežana D.
dc.date.accessioned2019-01-30T17:47:23Z
dc.date.available2019-01-30T17:47:23Z
dc.date.issued2015
dc.identifier.issn0378-5173
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1805
dc.description.abstractTo elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters (laurate or myristate) vs. polysorbate 80. A comprehensive physicochemical characterization indicated no significant influence of the solubilized nonsteroidal anti-inflammatory drug on the bicontinuous structure of blank formulations. To evaluate skin tolerability of isopropyl alcohol, a sucrose ester-based microemulsion containing transcutol P as a cosurfactant was also developed. The measured skin parameters strongly depended on the (co)surfactant type, showing higher compatibility of the microemulsions containing sucrose ester and isopropyl alcohol. In vitro release results, in vivo tape stripping and pharmacokinetics in rats confirmed superiority of the sucrose ester-over polysorbate-based microemulsions (total amounts of aceclofenac penetrated 60.81 +/- 5.97 and 60.86 +/- 3.67 vs. 27.00 +/- 5.09 mu g/cm(2), and its maximum plasma concentrations 275.57 +/- 109.49 and 281.31 +/- 76.76 vs. 150.23 +/- 69.74 ng/ml for sucrose laurate- and myristate- vs. polysorbate 80-based microemulsions, respectively). Hence, sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles. In conclusion, sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal aceclofenac delivery.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175076/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectBicontinuous microemulsionen
dc.subjectSucrose esteren
dc.subjectAceclofenacen
dc.subjectSkin irritation potentialen
dc.subjectTape strippingen
dc.subjectPharmacokineticsen
dc.titleBiocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performanceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГасперлин, Мирјана; Тодосијевиц, Марија Н; Савиц, Снезана Д; Лукиц, Милица З; Батиниц, Бојан Б; Ранђеловић, Данијела; Савиц, Мирослав М; Марковиц, Бојан Д;
dc.citation.volume496
dc.citation.issue2
dc.citation.spage931
dc.citation.epage941
dc.citation.other496(2): 931-941
dc.citation.rankM21
dc.description.otherAccepted version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3202]
dc.identifier.pmid26497615
dc.identifier.doi10.1016/j.ijpharm.2015.10.048
dc.identifier.scopus2-s2.0-84949571214
dc.identifier.wos000367384700079
dc.type.versionpublishedVersion


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