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dc.creatorPantelić, Nebojša Đ.
dc.creatorStanojković, Tatjana
dc.creatorZmejkovski, Bojana
dc.creatorSabo, Tibor
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2019-01-30T17:47:20Z
dc.date.available2019-01-30T17:47:20Z
dc.date.issued2015
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1803
dc.description.abstractFive novel gold(III) complexes of general formulas [AuCl2{(S,S)-R(2)eddip}]PF6, ((S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-Bu, n-Pe, i-Bu, i-Am, cPe; 1-5, respectively) were synthesized and characterized by UV/Vis, IR and NMR spectroscopy and mass spectrometry. DFT calculations indicated that (R,R)-N,N'-configuration diastereoisomers were the most stable for 1-5. 3 is stable in DMSO for at least 24 h, but immediate hydrolysis in PBS occurs. 3 is readily reduced with ascorbic acid and forms adducts with bovine serum albumin (BSA). In vitro anticancer activity of the gold(III) complexes against human cervix adenocarcinoma HeLa, human myelogenous leukemia K562, human melanoma Fem-x tumor cell lines, as well as against non-cancerous human embryonic lung fibroblast cell line MRC5 was determined using MIT assay. Complex 4 showed highest activity and selectivity (IC50(Femx) = 1.3 +/- 0.2; IC50(MRC-5)/IC50(Fem-x) = 72.5 +/- 12.4), 4 times more active and 28 times more selective than cisplatin. Complexes induced apoptotic mode of death in a time-dependent manner in HeLa cells.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectGold(III) complexesen
dc.subjectR(2)edda-type ligandsen
dc.subjectDFTen
dc.subjectApoptosisen
dc.subjectCell cycleen
dc.subjectcytotoxicityen
dc.titleIn vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКалудеровиц, Горан Н; Змејковски, Бојана; Пантелиц, Небојса; Станојковиц, Татјана П; Сабо, Тибор Ј;
dc.citation.volume90
dc.citation.spage766
dc.citation.epage774
dc.citation.other90: 766-774
dc.citation.rankM21
dc.identifier.pmid25528331
dc.identifier.doi10.1016/j.ejmech.2014.12.019
dc.identifier.rcubConv_3285
dc.identifier.scopus2-s2.0-84918804131
dc.identifier.wos000348951900060
dc.type.versionpublishedVersion


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