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Reactions of superoxide dismutases with HS-/H2S and superoxide radical anion: An in vitro EPR study

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2015
Authors
Bolic, Bojana
Mijuskovic, Ana
Popovic-Bijelic, Ana
Nikolić-Kokić, Aleksandra
Spasić, Snežana
Blagojevic, Dusko
Spasic, Mihajlo B
Spasojević, Ivan
Article (Published version)
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Abstract
Interactions of hydrogen sulfide (HS-/H2S), a reducing signaling species, with superoxide dimutases (SOD) are poorly understood. We applied low-T EPR spectroscopy to examine the effects of HS-/H2S and superoxide radical anion (O-2(-)) on metallocenters of FeSOD, MnSOD, and CuZnSOD. HS-/H2S did not affect FeSOD, whereas active centers of MnSOD and CuZnSOD were open to this agent. Cu2+ was reduced to Cu1+, while manganese appears to be released from MnSOD active center. Untreated and O-2(-) treated FeSOD and MnSOD predominantly show 5 d-electron systems, i.e. Fe3+ and Mn2+. Our study provides new details on the mechanisms of (patho)physiological effects of HS-/H2S.
Keywords:
Superoxide dismutase / EPR / H2S / Iron / Manganese / Copper
Source:
Nitric Oxide-Biology and Chemistry, 2015, 51, 19-23
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Projects:
  • Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)
  • Biomarkers in neurodegenerative and malignant processes (RS-41005)
Note:
  • Accepted version: http://cer.ihtm.bg.ac.rs/handle/123456789/3187

DOI: 10.1016/j.niox.2015.09.008

ISSN: 1089-8603

PubMed: 26436856

WoS: 000366065100003

Scopus: 2-s2.0-84944719548
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1787
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IHTM

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