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dc.creatorKlaus, Anita
dc.creatorKozarski, Maja S.
dc.creatorVunduk, Jovana
dc.creatorTodorović, Nina
dc.creatorJakovljević, Dragica
dc.creatorŽižak, Željko
dc.creatorPavlović, Vladimir B.
dc.creatorLevic, Steva
dc.creatorNikšić, Miomir
dc.creatorVan Griensven, Leo J. L. D.
dc.date.accessioned2019-01-30T17:46:25Z
dc.date.available2019-01-30T17:46:25Z
dc.date.issued2015
dc.identifier.issn0963-9969
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1761
dc.description.abstractPartially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity. The structural properties of FP and FNa samples were investigated by FT-IR and high resolution 1H- and 13C-NMR spectroscopy. From a group of various G- and G+ bacteria the antibacterial effects were highest against the G + B. cereus. FNa was the better antioxidant shown by the lower EC50 values of DPPH scavenging ability, ferric-reducing antioxidant power and ferrous ion-chelating ability. Ferric-reducing antioxidant power and ferrous ion-chelating ability were mostly linked to total polysaccharides, total- and beta-glucan content, as well as total protein content. Both extracts displayed a moderate dose dependent antiproliferative action towards malignant human breast cancer MDA-MB-453, cervical adenocarcinoma HeLa and myelogenous leukemia K562 cells not observed in the non cancer derived MRC-5 fibroblasts. The highest effect was found in HeLa cells for FP extract. The mean diameter of Ca-alginate bead loading FP was 960.7 mu m while the mean diameter of beads encapsulating FNa extract was 1051.7 mu m.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316004/EU//
dc.rightsrestrictedAccess
dc.sourceFood Research International
dc.subjectGrifola frondosaen
dc.subjectAntimicrobialen
dc.subjectAntioxidanten
dc.subjectcytotoxicityen
dc.subjectSEMen
dc.subjectEncapsulationen
dc.titleBiological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВундук, Јована; Јаковљевић, Драгица; Никсиц, Миомир; Левиц, Стева; Клаус, Aнита; Козарски, Маја; Тодоровић, Нина; Ван, Гриенсвен Лео Ј Л Д; Павловић, Владимир. Б.; Зизак, Зељко;
dc.citation.volume67
dc.citation.spage272
dc.citation.epage283
dc.citation.other67: 272-283
dc.citation.rankM21
dc.identifier.doi10.1016/j.foodres.2014.11.035
dc.identifier.rcubConv_3276
dc.identifier.scopus2-s2.0-84914145988
dc.identifier.wos000348619600034
dc.type.versionpublishedVersion


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