Electrochemical characterization of phenytoin and its derivatives on bare gold electrode
Само за регистроване кориснике
2015
Аутори
Trišović, NemanjaBožić, Bojan
Lović, Jelena
Vitnik, Vesna
Vitnik, Željko
Petrović, Slobodan D.
Avramov Ivić, Milka
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer ...of 1e(-) and 1 proton by irreversible, diffusion controlled process.
Кључне речи:
phenytoin derivatives / gold electrode / concentration dependency / DFT calculationИзвор:
Electrochimica Acta, 2015, 161, 378-387Издавач:
- Oxford : Pergamon-Elsevier Science Ltd
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Нов приступ дизајнирању материјала за конверзију и складиштење енергије (RS-MESTD-Basic Research (BR or ON)-172060)
- Моделирање и нумеричке симулације сложених вишечестичних система (RS-MESTD-Basic Research (BR or ON)-171017)
DOI: 10.1016/j.electacta.2015.02.114
ISSN: 0013-4686
WoS: 000351693500049
Scopus: 2-s2.0-84923375507
Институција/група
IHTMTY - JOUR AU - Trišović, Nemanja AU - Božić, Bojan AU - Lović, Jelena AU - Vitnik, Vesna AU - Vitnik, Željko AU - Petrović, Slobodan D. AU - Avramov Ivić, Milka PY - 2015 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1756 AB - Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Electrochimica Acta T1 - Electrochemical characterization of phenytoin and its derivatives on bare gold electrode VL - 161 SP - 378 EP - 387 DO - 10.1016/j.electacta.2015.02.114 ER -
@article{ author = "Trišović, Nemanja and Božić, Bojan and Lović, Jelena and Vitnik, Vesna and Vitnik, Željko and Petrović, Slobodan D. and Avramov Ivić, Milka", year = "2015", abstract = "Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Electrochimica Acta", title = "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode", volume = "161", pages = "378-387", doi = "10.1016/j.electacta.2015.02.114" }
Trišović, N., Božić, B., Lović, J., Vitnik, V., Vitnik, Ž., Petrović, S. D.,& Avramov Ivić, M.. (2015). Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta Oxford : Pergamon-Elsevier Science Ltd., 161, 378-387. https://doi.org/10.1016/j.electacta.2015.02.114
Trišović N, Božić B, Lović J, Vitnik V, Vitnik Ž, Petrović SD, Avramov Ivić M. Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta. 2015;161:378-387. doi:10.1016/j.electacta.2015.02.114 .
Trišović, Nemanja, Božić, Bojan, Lović, Jelena, Vitnik, Vesna, Vitnik, Željko, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode" in Electrochimica Acta, 161 (2015):378-387, https://doi.org/10.1016/j.electacta.2015.02.114 . .