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dc.creatorLeovac, Vukadin
dc.creatorRodić, Marko V.
dc.creatorJovanović, Ljiljana S.
dc.creatorJoksovic, Milan D.
dc.creatorStanojković, Tatjana
dc.creatorVujčić, Miroslava
dc.creatorSladić, Dušan
dc.creatorMarkovic, Violeta
dc.creatorVojinovic-Jesic, Ljiljana S
dc.date.accessioned2019-01-30T17:45:55Z
dc.date.available2019-01-30T17:45:55Z
dc.date.issued2015
dc.identifier.issn1434-1948
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1735
dc.description.abstractFive pentacoordinate copper(II) complexes with 2-acetylpyridine or di(2-pyridyl) ketone 1-adamantoyl hydrazone ligands (Adpy and Addpy, respectively) of the formulae [CuCl2(Adpy)] (1), [Cu-2(-Cl)(2)(Adpy-H)(2)] (2), [Cu(NCS)(2)(Adpy)] (3), [Cu-2(-Cl)(2)(Addpy-H)(2)] (4), and [Cu-2(NCS)(2)(-Addpy-H)(2)] (5) were synthesized and characterized by spectral, electrochemical, and X-ray structural analysis. Flow cytometry and morphological analysis confirmed that the copper(II) complexes 2 and 5 induced accumulation of a sub-G1 phase population, and fluorescence microscopy indicated the presence of large cells in apoptosis. The interaction of the copper(II) complexes with calf thymus DNA (CT-DNA) was monitored by changes in their UV/Vis spectra. The observed intrinsic binding constants for 2 and 5 (K-b = 1.77x10(6) and 3.58x10(6) M-1, respectively) together with ethidium displacement fluorescence experiments indicate intercalative binding. Complexes 2 and 5 showed nuclease activity against pUC19 plasmid DNA.en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationProvincial Secretariat for Science and Technological Development of Vojvodina
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Inorganic Chemistry
dc.subjectBioinorganic chemistryen
dc.subjectMedicinal chemistryen
dc.subjectAntitumor agentsen
dc.subjectDNA cleavageen
dc.subjectcytotoxicityen
dc.subjectHydrazonesen
dc.subjectCopperen
dc.subjectNen
dc.subjectO ligandsen
dc.titleTransition Metal Complexes with 1-Adamantoyl Hydrazones - Cytotoxic Copper(II) Complexes of Tri- and Tetradentate Pyridine Chelators Containing an Adamantane Ring Systemen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарковиц, Виолета; Вујчић, Мирослава; Војиновиц-Јесиц, Љиљана С; Станојковиц, Татјана; Сладиц, Дусан; Јоксовиц, Милан Д; Јовановиц, Љиљана С; Родић, Марко В.; Леовац, Вукадин М;
dc.citation.issue5
dc.citation.spage882
dc.citation.epage895
dc.citation.other(5): 882-895
dc.citation.rankM22
dc.identifier.doi10.1002/ejic.201403050
dc.identifier.scopus2-s2.0-84922475134
dc.identifier.wos000349435300015
dc.type.versionpublishedVersion


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