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dc.creatorTolic, Ljiljana
dc.creatorLović, Jelena
dc.creatorPetrović, Slobodan D.
dc.creatorMijin, Dušan
dc.creatorGrujic, Svetlana
dc.creatorLausevic, Mila
dc.creatorAvramov Ivić, Milka
dc.date.accessioned2019-01-30T17:45:40Z
dc.date.available2019-01-30T17:45:40Z
dc.date.issued2015
dc.identifier.issn1388-2481
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1725
dc.description.abstractAnisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172060/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172007/RS//
dc.rightsrestrictedAccess
dc.sourceElectrochemistry Communications
dc.subjectAnisomycinen
dc.subjectElectroactivityen
dc.subjectSWVen
dc.subjectHPLC-MS/MSen
dc.titleInvestigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГрујиц, Светлана; Ловић, Јелена; Aврамов Ивић, Милка; Толиц, Љиљана; Мијин, Дусан; Петровић, Слободан Д.; Лаусевиц, Мила;
dc.citation.volume58
dc.citation.spage20
dc.citation.epage24
dc.citation.other58: 20-24
dc.citation.rankM21
dc.identifier.doi10.1016/j.elecom.2015.05.017
dc.identifier.rcubConv_3395
dc.identifier.scopus2-s2.0-84934888024
dc.identifier.wos000360514600005
dc.type.versionpublishedVersion


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