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dc.creatorŠukalović, Vladimir
dc.creatorŠoškić, Vukić
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:45:19Z
dc.date.available2019-01-30T17:45:19Z
dc.date.issued2015
dc.identifier.issn0929-8673
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1710
dc.description.abstractResearch on dopamine (DA) and its receptors, and in particular the D2 receptor subclass, has been an intriguing and fast developing scientific field in the past 35 years. Methods of medicinal chemistry, molecular and structural biology as well as computational chemistry were used in the studies of DA receptors (DRs). Early attempts to describe DRs were based on a small amount of experimental data available and produced crude models at best. Once crystal structures of bacteriorhodopsin, rhodopsine, various G-protein coupled receptors, and finally D3 DR receptor became available, better and more detailed D2 DR receptor models emerged. These models gave us an insight into the mechanism of ligand-receptor interactions, and paved the way for the synthesis of new dopaminergic compounds, both agonists and antagonists and possible drugs for the treatment of different imbalances of the dopaminergic system. This review covers the key discoveries on the path to the creation of the D2 DR receptor model.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Medicinal Chemistry
dc.subject3D structureen
dc.subjectcomputational chemistryen
dc.subjectdopamineen
dc.subjectGPCRen
dc.subjecthomology modelingen
dc.subjectreceptoren
dc.titleModeling of Dopamine D2 Receptor - Overview of 35-Year Evolutionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШукаловић, Владимир; Костић Рајачић, Слађана; Соскиц, Вукиц;
dc.citation.volume22
dc.citation.issue25
dc.citation.spage2972
dc.citation.epage2990
dc.citation.other22(25): 2972-2990
dc.citation.rankM21
dc.identifier.pmid26180002
dc.identifier.doi10.2174/0929867322666150716114316
dc.identifier.rcubConv_3391
dc.identifier.scopus2-s2.0-84942098407
dc.identifier.wos000360375400005
dc.type.versionpublishedVersion


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