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dc.creatorCabarkapa, Andrea
dc.creatorBorozan, Sunčica
dc.creatorŽivković, Lada
dc.creatorMilanovic-Cabarkapa, Mirjana
dc.creatorStojanović, Srđan
dc.creatorBajic, Vladan
dc.creatorSpremo-Potparević, Biljana
dc.date.accessioned2019-01-30T17:45:15Z
dc.date.available2019-01-30T17:45:15Z
dc.date.issued2015
dc.identifier.issn0277-2248
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1706
dc.description.abstractThe aim of this study was to determine oxidative alterations leading to cellular dysfunctions in Pb-exposed subjects by evaluating damage to all major classes of biomolecules in the cell, lipid peroxidation, protein and DNA damage and determine relationships between parameters of Pb toxicity and specific biomarkers of oxidative damage.Analysis was conducted of smelter workers with high blood Pb and urine aminolevulinic acid levels and slightly elevated values of coproporphyrin and erythrocyte protoporphyrin IX. Significant decreases of thiol groups and increases in carbonyl groups as protein degradation end products, and of nitrite were detected. Elevated rates of lipid peroxidation and rises in the activities of the antioxidant enzymes Cu-Zn superoxide dismutase and catalase were also observed. Both enzymes showed positive correlations with the blood lead levels and urine coproporphyrin, while thiol groups correlated negatively with the same indices. The genotoxic potential of lead was manifested through an increased number of DNA-damaged cells. Increased activities of serum lactate dehydrogenase isoenzymes indicated cellular damage in the lungs, kidneys, and liver. These lead-induced impairments should be taken into consideration in the assessment of Pb-related health hazards.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceToxicological and Environmental Chemistry
dc.subjectlead (Pb)en
dc.subjectoxidative stressen
dc.subjectDNA damageen
dc.subjectprotein oxidative modificationen
dc.subjectcell membrane damageen
dc.titleImplications of oxidative stress in occupational exposure to lead on a cellular levelen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБорозан, Сунцица; Бајиц, Владан; Милановиц-Цабаркапа, Мирјана; Стојановић, Срђан; Цабаркапа, Aндреа; Зивковиц, Лада; Спремо-Потпаревиц, Биљана;
dc.citation.volume97
dc.citation.issue6
dc.citation.spage799
dc.citation.epage813
dc.citation.other97(6): 799-813
dc.citation.rankM23
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3121]
dc.identifier.doi10.1080/02772248.2015.1060973
dc.identifier.rcubConv_3387
dc.identifier.scopus2-s2.0-84938743717
dc.identifier.wos000359795300009
dc.type.versionpublishedVersion


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