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Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands

Authorized Users Only
2015
Authors
Todorović, Tamara
Grubišić, Sonja
Pregelj, Matej
Jagodic, Marko
Misirlic-Dencic, Sonja
Dulovic, Marija
Markovic, Ivanka
Klisurić, Olivera
Malešević, Aleksandar S.
Mitić, Dragana
Anđelković, Katarina
Filipovic, Nenad
Article (Published version)
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Abstract
Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II c...omplexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.

Keywords:
Copper / Magnetic properties / Density functional calculations / Medicinal chemistry / cytotoxicity / Apoptosis
Source:
European Journal of Inorganic Chemistry, 2015, 23, 3921-3931
Publisher:
  • Wiley-V C H Verlag Gmbh, Weinheim
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-41025)

DOI: 10.1002/ejic.201500349

ISSN: 1434-1948

WoS: 000359627100013

Scopus: 2-s2.0-84939270154
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1705
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