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dc.creatorBozinovic, Nina
dc.creatorNovaković, Irena
dc.creatorKostić Rajačić, Slađana
dc.creatorOpsenica, Igor
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:45:08Z
dc.date.available2019-01-30T17:45:08Z
dc.date.issued2015
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1702
dc.description.abstractA series of new pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The pyridobenzazepine derivatives showed better antibacterial and antifungal activity than the corresponding dipyridoazepine analogue. Among the synthesized azepines, derivative 8 displayed potent activity against the tested bacteria (MIC ranged 39-78 mu g mL(-1)), while azepine 12 showed promising antifungal activity (MIC ranged 156-313 mu g mL(-1)). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.en
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//
dc.relationSerbian Academy of Sciences and Arts
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectazepinesen
dc.subjectthiepinesen
dc.subjectheterocyclesen
dc.subjectpalladiumen
dc.subjectantibacterialsen
dc.subjectantifungalen
dc.titleSynthesis and antimicrobial activity of azepine and thiepine derivativesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractОпсеница, Игор М; Солаја, Богдан A; Новаковић, Ирена; Бозиновиц, Нина; Костић Рајачић, Слађана;
dc.citation.volume80
dc.citation.issue7
dc.citation.spage839
dc.citation.epage852
dc.citation.other80(7): 839-852
dc.citation.rankM23
dc.identifier.doi10.2298/JSC150116013B
dc.identifier.rcubConv_3383
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8153/1700.pdf
dc.identifier.scopus2-s2.0-84938924652
dc.identifier.wos000359326100001
dc.type.versionpublishedVersion


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