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dc.creatorGođevac, Dejan
dc.creatorStanković, Jovana
dc.creatorNovaković, Miroslav
dc.creatorAnđelković, Boban D.
dc.creatorDajić-Stevanović, Zora
dc.creatorPetrovic, Milica
dc.creatorStanković, Miroslava
dc.date.accessioned2019-01-30T17:44:30Z
dc.date.available2019-01-30T17:44:30Z
dc.date.issued2015
dc.identifier.issn0163-3864
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1672
dc.description.abstractFrom the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogenetic damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6.en
dc.publisherAmerican Chemical Society (ACS)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316004/EU//
dc.rightsrestrictedAccess
dc.sourceJournal of Natural Products
dc.titlePhenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГођевац, Дејан; Aнђелковић, Бобан Д.; Дајиц-Стевановиц, Зора; Станковић, Јована; Петровиц, Милица; Станковиц, Мирослава; Новаковић, Мирослав;
dc.citation.volume78
dc.citation.issue9
dc.citation.spage2198
dc.citation.epage2204
dc.citation.other78(9): 2198-2204
dc.citation.rankM21
dc.identifier.pmid26290401
dc.identifier.doi10.1021/acs.jnatprod.5b00273
dc.identifier.scopus2-s2.0-84942636560
dc.identifier.wos000362056200007
dc.type.versionpublishedVersion


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