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dc.creatorDinić, Jelena
dc.creatorRandelovic, Teodora
dc.creatorStankovic, Tijana
dc.creatorDragoj, Miodrag
dc.creatorIsaković, Aleksandra
dc.creatorNovaković, Miroslav
dc.creatorPešić, Milica
dc.date.accessioned2019-01-30T17:44:27Z
dc.date.available2019-01-30T17:44:27Z
dc.date.issued2015
dc.identifier.issn0367-326X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1668
dc.description.abstractMedicinal plants are recognized from ancient times as a source of diverse therapeutic agents and many of them are used as dietary supplements. Comprehensive approaches are needed that would identify bioactive components with evident activity against specific indications and provide a better link between science (ethno-botany, chemistry, biology and pharmacology) and market Recently, the bark of black alder (Alnus glutinosa) appeared at market in the form of food supplement for treatment of different skin conditions. This study aimed to evaluate protective effects of two diarylheptanoids isolated from the bark of black alder: platyphylloside, 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-beta-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-beta-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2) towards doxorubicin damaging activity. To that end, we employed HaCaT cells, non-cancerous human keratinocytes commonly used for skin regenerative studies. Diarylheptanoids significantly antagonized the effects of doxorubicin by lowering the sensitivity of HaCaT cells to this drug. Compound 2 prevented doxorubicin-induced cell death by activating autophagy. Both land 2 protected HaCaT cells against doxorubicin-induced DNA damage. They significantly promoted migration and affected F-actin distribution. These results indicate that chemo-protective effects of diarylheptanoids may occur at multiple subcellular levels. Therefore, diarylheptanoids 1 and 2 could be considered as protective agents for non-cancerous dividing cells during chemotherapy.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourceFitoterapia
dc.subjectDiarylheptanoiden
dc.subjectCurcuminen
dc.subjectDoxorubicinen
dc.subjectDNA damageen
dc.subjectCell motilityen
dc.subjectChemoprotectionen
dc.titleChemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДрагој, Миодраг; Песиц, Милица; Новаковић, Мирослав; Ранделовиц, Теодора; Станковиц, Тијана; Исаковиц, Aлександра; Диниц, Јелена;
dc.citation.volume105
dc.citation.spage169
dc.citation.epage176
dc.citation.other105: 169-176
dc.citation.rankM22
dc.description.otherAccepted version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3185]
dc.identifier.pmid26162555
dc.identifier.doi10.1016/j.fitote.2015.07.003
dc.identifier.rcubConv_3420
dc.identifier.scopus2-s2.0-84937539499
dc.identifier.wos000361401500027
dc.type.versionpublishedVersion


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