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Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes

Authorized Users Only
2015
Authors
Dinic, Jelena
Randelovic, Teodora
Stankovic, Tijana
Dragoj, Miodrag
Isaković, Aleksandra
Novaković, Miroslav
Pešić, Milica
Article (Published version)
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Abstract
Medicinal plants are recognized from ancient times as a source of diverse therapeutic agents and many of them are used as dietary supplements. Comprehensive approaches are needed that would identify bioactive components with evident activity against specific indications and provide a better link between science (ethno-botany, chemistry, biology and pharmacology) and market Recently, the bark of black alder (Alnus glutinosa) appeared at market in the form of food supplement for treatment of different skin conditions. This study aimed to evaluate protective effects of two diarylheptanoids isolated from the bark of black alder: platyphylloside, 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-beta-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-beta-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2) towards doxorubicin damaging activity. To that end, we employed HaCaT cells, non-cancerous human keratinocytes commonly used for skin regenerative studies.... Diarylheptanoids significantly antagonized the effects of doxorubicin by lowering the sensitivity of HaCaT cells to this drug. Compound 2 prevented doxorubicin-induced cell death by activating autophagy. Both land 2 protected HaCaT cells against doxorubicin-induced DNA damage. They significantly promoted migration and affected F-actin distribution. These results indicate that chemo-protective effects of diarylheptanoids may occur at multiple subcellular levels. Therefore, diarylheptanoids 1 and 2 could be considered as protective agents for non-cancerous dividing cells during chemotherapy.

Keywords:
Diarylheptanoid / Curcumin / Doxorubicin / DNA damage / Cell motility / Chemoprotection
Source:
Fitoterapia, 2015, 105, 169-176
Publisher:
  • Elsevier Science Bv, Amsterdam
Projects:
  • Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-41031)
Note:
  • Accepted version: http://cer.ihtm.bg.ac.rs/handle/123456789/3185

DOI: 10.1016/j.fitote.2015.07.003

ISSN: 0367-326X

PubMed: 26162555

WoS: 000361401500027

Scopus: 2-s2.0-84937539499
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1668
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