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dc.creatorKozarski, Maja S.
dc.creatorKlaus, Anita
dc.creatorVunduk, Jovana
dc.creatorŽižak, Željko
dc.creatorNikšić, Miomir
dc.creatorJakovljević, Dragica
dc.creatorVrvić, Miroslav
dc.creatorVan Griensven, Leo J. L. D.
dc.date.accessioned2019-01-30T17:44:25Z
dc.date.available2019-01-30T17:44:25Z
dc.date.issued2015
dc.identifier.issn2042-6496
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1666
dc.description.abstractThe methanolic extract of the wild edible mushroom Cantharellus cibarius Fr. (chanterelle) was analyzed for in vitro antioxidative, cytotoxic, antihypertensive and antibacterial activities. Various primary and secondary metabolites were found. Phenols were the major antioxidant components found in the extract (49.8 mg g(-1)), followed by flavonoids, whose content was approximately 86% of the total phenol content. Antioxidant activity, measured by four different methods, was high for inhibition of lipid peroxidation (EC50 = 1.21 mg mL(-1)) and chelating ability (EC50 = 0.64 mg mL(-1)). The antioxidant activity of the C. cibarius methanol extract was achieved through chelating iron compared to hydrogen atom and/or electron transfer. The extract showed good selectivity in cytotoxicity on human cervix adenocarcinoma HeLa, breast carcinoma MDA-MB-453 and human myelogenous leukemia K562, compared to normal control human fetal lung fibroblasts MRC-5 and human lung bronchial epithelial cells BEAS-2B. The extract had inhibitory activity against angiotensin converting I enzyme (ACE) (IC50 = 0.063 mg mL(-1)). The extract revealed selective antimicrobial activity against Gram-positive bacteria with the highest potential against E. faecalis. The medicinal and health benefits, observed in wild C. cibarius mushroom, seem an additional reason for its traditional use as a popular delicacy food.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316004/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsopenAccess
dc.sourceFood & Function
dc.titleNutraceutical properties of the methanolic extract of edible mushroom Cantharellus cibarius (Fries): primary mechanismsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈаковљевић, Драгица; Козарски, Маја; Клаус, Aнита; Вундук, Јована; Зизак, Зељко; Никсиц, Миомир; Врвиц, Мирослав М; Ван, Гриенсвен Лео Ј Л Д;
dc.citation.volume6
dc.citation.issue6
dc.citation.spage1875
dc.citation.epage1886
dc.citation.other6(6): 1875-1886
dc.citation.rankM21
dc.identifier.pmid25943486
dc.identifier.doi10.1039/c5fo00312a
dc.identifier.rcubConv_3350
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8118/1664.pdf
dc.identifier.scopus2-s2.0-84931054008
dc.identifier.wos000356058000012
dc.type.versionpublishedVersion


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