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dc.creatorBulatović, Mirna
dc.creatorKaluderovic, Milena R
dc.creatorMojic, Marija
dc.creatorZmejkovski, Bojana
dc.creatorHey-Hawkins, Evamarie
dc.creatorVidakovic, Melita
dc.creatorGrdovic, Nevena
dc.creatorKaluđerović, Goran N.
dc.creatorMijatović, Sanja
dc.creatorMaksimović-Ivanić, Danijela D.
dc.date.accessioned2019-01-30T17:44:05Z
dc.date.available2019-01-30T17:44:05Z
dc.date.issued2015
dc.identifier.issn0014-2999
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1650
dc.description.abstract(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV), [PtCl4(iBu(2)eddp)]. shows an improved pharmacological profile in comparison to cisplatin. This is manifested through accelerated dying process led by necrotic cell death, reflected through mitochondrial collapse, strong ATP depletion and reactive oxygen species production. Loss of mitochondrial potential was further followed with intensive apoptosis that finalized with DNA fragmentation. Different dynamic of tumoricidal action could be partly ascribed to less affected repair mechanisms in comparison to cisplatin. Importantly, [PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts suggesting different intracellular response of normal vs. tumor cells. This selectivity toward malignant phenotype is further confirmed by retained tumoricidal potential in hypoxic conditions, while cisplatin became completely inefficient.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationSMWK - 33707045
dc.relationSAB (ESF) - 100147954
dc.relationFree State of Saxony - 100099597
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmacology
dc.subjectPlatinum(IV) complexen
dc.subjectCisplatinen
dc.subjectATP depletionen
dc.subjectMitochondrial collapseen
dc.subjectOxidative stressen
dc.subjectHypoxic conditionsen
dc.titleImproved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаксимовиц-Иваниц, Данијела; Видаковиц, Мелита; Мојиц, Марија; Змејковски, Бојана; Хеy-Хаwкинс, Евамарие; Калудеровиц, Милена Р; Булатовиц, Мирна; Грдовиц, Невена; Калудеровиц, Горан Н; Мијатовиц, Сања;
dc.citation.volume760
dc.citation.spage136
dc.citation.epage144
dc.citation.other760: 136-144
dc.citation.rankM22
dc.identifier.pmid25912798
dc.identifier.doi10.1016/j.ejphar.2015.04.012
dc.identifier.rcubConv_3348
dc.identifier.scopus2-s2.0-84929457797
dc.identifier.wos000355664200017
dc.type.versionpublishedVersion


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