Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
TY - JOUR
AU - Novaković, Miroslav
AU - Stanković, Miroslava
AU - Vučković, Ivan
AU - Todorović, Nina
AU - Trifunović, Snežana
AU - Apostolovic, Danijela
AU - Mandić, Boris
AU - Veljić, Milan
AU - Marin, Petar D.
AU - Tešević, Vele
AU - Vajs, Vlatka
AU - Milosavljević, Slobodan
PY - 2014
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1596
AB - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB - Wiley-V C H Verlag Gmbh, Weinheim
T2 - Chemistry & Biodiversity
T1 - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL - 11
IS - 6
SP - 872
EP - 885
DO - 10.1002/cbdv.201300277
ER -
@article{
author = "Novaković, Miroslav and Stanković, Miroslava and Vučković, Ivan and Todorović, Nina and Trifunović, Snežana and Apostolovic, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277"
}
Novaković, M., Stanković, M., Vučković, I., Todorović, N., Trifunović, S., Apostolovic, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277
Novaković M, Stanković M, Vučković I, Todorović N, Trifunović S, Apostolovic D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277 .
Novaković, Miroslav, Stanković, Miroslava, Vučković, Ivan, Todorović, Nina, Trifunović, Snežana, Apostolovic, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry & Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 . .
