Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
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2014
Authors
Novaković, Miroslav
Stanković, Miroslava

Vučković, Ivan

Todorović, Nina

Trifunović, Snežana

Apostolovic, Danijela

Mandić, Boris

Veljić, Milan

Marin, Petar D.

Tešević, Vele

Vajs, Vlatka
Milosavljević, Slobodan

Article (Published version)

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Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
Source:
Chemistry & Biodiversity, 2014, 11, 6, 872-885Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-256716)
DOI: 10.1002/cbdv.201300277
ISSN: 1612-1872
PubMed: 24934673
WoS: 000337726800003
Scopus: 2-s2.0-84902822329
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IHTMTY - JOUR AU - Novaković, Miroslav AU - Stanković, Miroslava AU - Vučković, Ivan AU - Todorović, Nina AU - Trifunović, Snežana AU - Apostolovic, Danijela AU - Mandić, Boris AU - Veljić, Milan AU - Marin, Petar D. AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1596 AB - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Chemistry & Biodiversity T1 - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection VL - 11 IS - 6 SP - 872 EP - 885 DO - 10.1002/cbdv.201300277 ER -
@article{ author = "Novaković, Miroslav and Stanković, Miroslava and Vučković, Ivan and Todorović, Nina and Trifunović, Snežana and Apostolovic, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan", year = "2014", abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Chemistry & Biodiversity", title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection", volume = "11", number = "6", pages = "872-885", doi = "10.1002/cbdv.201300277" }
Novaković, M., Stanković, M., Vučković, I., Todorović, N., Trifunović, S., Apostolovic, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885. https://doi.org/10.1002/cbdv.201300277
Novaković M, Stanković M, Vučković I, Todorović N, Trifunović S, Apostolovic D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity. 2014;11(6):872-885. doi:10.1002/cbdv.201300277 .
Novaković, Miroslav, Stanković, Miroslava, Vučković, Ivan, Todorović, Nina, Trifunović, Snežana, Apostolovic, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry & Biodiversity, 11, no. 6 (2014):872-885, https://doi.org/10.1002/cbdv.201300277 . .