Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
Authorized Users Only
Marin, Petar D.
Article (Published version)
MetadataShow full item record
Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
Source:Chemistry & Biodiversity, 2014, 11, 6, 872-885
- Wiley-V C H Verlag Gmbh, Weinheim