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dc.creatorRistic, Aleksandar J.
dc.creatorSokic, Dragoslav
dc.creatorBaščarević, Vladimir
dc.creatorSpasić, Snežana
dc.creatorVojvodic, Nikola
dc.creatorSavić, Slobodan
dc.creatorRaičević, Savo
dc.creatorKovacevic, Masa
dc.creatorSavic, Danijela
dc.creatorSpasojević, Ivan
dc.date.accessioned2019-01-30T17:42:42Z
dc.date.available2019-01-30T17:42:42Z
dc.date.issued2014
dc.identifier.issn0013-9580
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1583
dc.description.abstractAn altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control [C]: 3.57 +/- 0.33; p LT 0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409 +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61; p LT 0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/- 25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS. A PowerPoint slide summarizing this article is available for download in the Supporting Information section .en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsopenAccess
dc.sourceEpilepsia
dc.subjectMesial temporal epilepsyen
dc.subjectHippocampal sclerosisen
dc.subjectCopperen
dc.subjectManganeseen
dc.subjectElectrolytesen
dc.titleMetals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавиц, Слободан; Раицевиц, Саво; Ковацевиц, Маса; Савиц, Данијела; Спасић, Снежана; Сокиц, Драгослав; Ристиц, Aлександар Ј.; Спасојевиц, Иван; Басцаревиц, Владимир; Војводиц, Никола;
dc.citation.volume55
dc.citation.issue5
dc.citation.other55(5):
dc.citation.rankM21
dc.identifier.pmid24673751
dc.identifier.doi10.1111/epi.12593
dc.identifier.rcubConv_3155
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8050/1581.pdf
dc.identifier.scopus2-s2.0-84901286466
dc.identifier.wos000336623200001
dc.type.versionpublishedVersion


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