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Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy
dc.creator | Ristic, Aleksandar J. | |
dc.creator | Sokic, Dragoslav | |
dc.creator | Baščarević, Vladimir | |
dc.creator | Spasić, Snežana | |
dc.creator | Vojvodic, Nikola | |
dc.creator | Savić, Slobodan | |
dc.creator | Raičević, Savo | |
dc.creator | Kovacevic, Masa | |
dc.creator | Savic, Danijela | |
dc.creator | Spasojević, Ivan | |
dc.date.accessioned | 2019-01-30T17:42:42Z | |
dc.date.available | 2019-01-30T17:42:42Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0013-9580 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1583 | |
dc.description.abstract | An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control [C]: 3.57 +/- 0.33; p LT 0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409 +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61; p LT 0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/- 25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS. A PowerPoint slide summarizing this article is available for download in the Supporting Information section . | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS// | |
dc.rights | openAccess | |
dc.source | Epilepsia | |
dc.subject | Mesial temporal epilepsy | en |
dc.subject | Hippocampal sclerosis | en |
dc.subject | Copper | en |
dc.subject | Manganese | en |
dc.subject | Electrolytes | en |
dc.title | Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Савиц, Слободан; Раицевиц, Саво; Ковацевиц, Маса; Савиц, Данијела; Спасић, Снежана; Сокиц, Драгослав; Ристиц, Aлександар Ј.; Спасојевиц, Иван; Басцаревиц, Владимир; Војводиц, Никола; | |
dc.citation.volume | 55 | |
dc.citation.issue | 5 | |
dc.citation.spage | e34 | |
dc.citation.epage | e37 | |
dc.citation.other | 55(5): | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 24673751 | |
dc.identifier.doi | 10.1111/epi.12593 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8050/1581.pdf | |
dc.identifier.scopus | 2-s2.0-84901286466 | |
dc.identifier.wos | 000336623200001 | |
dc.type.version | publishedVersion |