Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy

2014
Аутори
Ristic, Aleksandar J.Sokic, Dragoslav
Baščarević, Vladimir
Spasić, Snežana

Vojvodic, Nikola
Savić, Slobodan
Raičević, Savo
Kovacevic, Masa
Savic, Danijela

Spasojević, Ivan

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control [C]: 3.57 +/- 0.33; p LT 0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409 +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61; p LT 0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/- 25; p=0.010). Zinc, iron, calcium, and magn...esium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS. A PowerPoint slide summarizing this article is available for download in the Supporting Information section .
Кључне речи:
Mesial temporal epilepsy / Hippocampal sclerosis / Copper / Manganese / ElectrolytesИзвор:
Epilepsia, 2014, 55, 5Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-173014)
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-43004)
DOI: 10.1111/epi.12593
ISSN: 0013-9580
PubMed: 24673751
WoS: 000336623200001
Scopus: 2-s2.0-84901286466
Институција/група
IHTMTY - JOUR AU - Ristic, Aleksandar J. AU - Sokic, Dragoslav AU - Baščarević, Vladimir AU - Spasić, Snežana AU - Vojvodic, Nikola AU - Savić, Slobodan AU - Raičević, Savo AU - Kovacevic, Masa AU - Savic, Danijela AU - Spasojević, Ivan PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1583 AB - An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control [C]: 3.57 +/- 0.33; p LT 0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409 +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61; p LT 0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/- 25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS. A PowerPoint slide summarizing this article is available for download in the Supporting Information section . PB - Wiley-Blackwell, Hoboken T2 - Epilepsia T1 - Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy VL - 55 IS - 5 DO - 10.1111/epi.12593 ER -
@article{ author = "Ristic, Aleksandar J. and Sokic, Dragoslav and Baščarević, Vladimir and Spasić, Snežana and Vojvodic, Nikola and Savić, Slobodan and Raičević, Savo and Kovacevic, Masa and Savic, Danijela and Spasojević, Ivan", year = "2014", abstract = "An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control [C]: 3.57 +/- 0.33; p LT 0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409 +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61; p LT 0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/- 25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS. A PowerPoint slide summarizing this article is available for download in the Supporting Information section .", publisher = "Wiley-Blackwell, Hoboken", journal = "Epilepsia", title = "Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy", volume = "55", number = "5", doi = "10.1111/epi.12593" }
Ristic, A. J., Sokic, D., Baščarević, V., Spasić, S., Vojvodic, N., Savić, S., Raičević, S., Kovacevic, M., Savic, D.,& Spasojević, I.. (2014). Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy. in Epilepsia Wiley-Blackwell, Hoboken., 55(5). https://doi.org/10.1111/epi.12593
Ristic AJ, Sokic D, Baščarević V, Spasić S, Vojvodic N, Savić S, Raičević S, Kovacevic M, Savic D, Spasojević I. Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy. in Epilepsia. 2014;55(5). doi:10.1111/epi.12593 .
Ristic, Aleksandar J., Sokic, Dragoslav, Baščarević, Vladimir, Spasić, Snežana, Vojvodic, Nikola, Savić, Slobodan, Raičević, Savo, Kovacevic, Masa, Savic, Danijela, Spasojević, Ivan, "Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy" in Epilepsia, 55, no. 5 (2014), https://doi.org/10.1111/epi.12593 . .