The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
TY - JOUR
AU - Mladenović, Aleksandar R.
AU - Mijin, Dušan
AU - Drmanić, Saša Ž.
AU - Vajs, Vlatka
AU - Jovanović, Vladislava M.
AU - Petrović, Slobodan D.
AU - Avramov Ivić, Milka
PY - 2014
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1577
AB - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
PB - Wiley-Blackwell, Malden
T2 - Electroanalysis
T1 - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
VL - 26
IS - 5
SP - 893
EP - 897
DO - 10.1002/elan.201400034
ER -
@article{
author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša Ž. and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2014",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/1577",
abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.",
publisher = "Wiley-Blackwell, Malden",
journal = "Electroanalysis",
title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode",
volume = "26",
number = "5",
pages = "893-897",
doi = "10.1002/elan.201400034"
}
Mladenović, A. R., Mijin, D., Drmanić, S. Ž., Vajs, V., Jovanović, V. M., Petrović, S. D.,& Avramov Ivić, M. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode.
Electroanalysis
Wiley-Blackwell, Malden., 26(5), 893-897.
https://doi.org/10.1002/elan.201400034
Mladenović AR, Mijin D, Drmanić SŽ, Vajs V, Jovanović VM, Petrović SD, Avramov Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. Electroanalysis. 2014;26(5):893-897
Mladenović Aleksandar R., Mijin Dušan, Drmanić Saša Ž., Vajs Vlatka, Jovanović Vladislava M., Petrović Slobodan D., Avramov Ivić Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" Electroanalysis, 26, no. 5 (2014):893-897,
https://doi.org/10.1002/elan.201400034 .
