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Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode

Authorized Users Only
2014
Authors
Mladenović, Aleksandar R.
Mijin, Dušan
Drmanić, Saša Ž.
Vajs, Vlatka
Jovanović, Vladislava M.
Petrović, Slobodan D.
Avramov Ivić, Milka
Article (Published version)
Metadata
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Abstract
The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
Keywords:
Cyclic voltammetry / Donepezil / Gold electrode / Oxidation / Square wave voltammetry
Source:
Electroanalysis, 2014, 26, 5, 893-897
Publisher:
  • Wiley-Blackwell, Malden
Funding / projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)

DOI: 10.1002/elan.201400034

ISSN: 1040-0397

WoS: 000335997600001

Scopus: 2-s2.0-84900331905
[ Google Scholar ]
10
11
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1577
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Mladenović, Aleksandar R.
AU  - Mijin, Dušan
AU  - Drmanić, Saša Ž.
AU  - Vajs, Vlatka
AU  - Jovanović, Vladislava M.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1577
AB  - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
PB  - Wiley-Blackwell, Malden
T2  - Electroanalysis
T1  - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
VL  - 26
IS  - 5
SP  - 893
EP  - 897
DO  - 10.1002/elan.201400034
ER  - 
@article{
author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša Ž. and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2014",
abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.",
publisher = "Wiley-Blackwell, Malden",
journal = "Electroanalysis",
title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode",
volume = "26",
number = "5",
pages = "893-897",
doi = "10.1002/elan.201400034"
}
Mladenović, A. R., Mijin, D., Drmanić, S. Ž., Vajs, V., Jovanović, V. M., Petrović, S. D.,& Avramov Ivić, M.. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis
Wiley-Blackwell, Malden., 26(5), 893-897.
https://doi.org/10.1002/elan.201400034
Mladenović AR, Mijin D, Drmanić SŽ, Vajs V, Jovanović VM, Petrović SD, Avramov Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis. 2014;26(5):893-897.
doi:10.1002/elan.201400034 .
Mladenović, Aleksandar R., Mijin, Dušan, Drmanić, Saša Ž., Vajs, Vlatka, Jovanović, Vladislava M., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" in Electroanalysis, 26, no. 5 (2014):893-897,
https://doi.org/10.1002/elan.201400034 . .

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