Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
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2014
Authors
Mladenović, Aleksandar R.
Mijin, Dušan

Drmanić, Saša Ž.

Vajs, Vlatka
Jovanović, Vladislava M.

Petrović, Slobodan D.
Avramov Ivić, Milka

Article (Published version)

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Show full item recordAbstract
The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
Keywords:
Cyclic voltammetry / Donepezil / Gold electrode / Oxidation / Square wave voltammetrySource:
Electroanalysis, 2014, 26, 5, 893-897Publisher:
- Wiley-Blackwell, Malden
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
DOI: 10.1002/elan.201400034
ISSN: 1040-0397
WoS: 000335997600001
Scopus: 2-s2.0-84900331905
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IHTMTY - JOUR AU - Mladenović, Aleksandar R. AU - Mijin, Dušan AU - Drmanić, Saša Ž. AU - Vajs, Vlatka AU - Jovanović, Vladislava M. AU - Petrović, Slobodan D. AU - Avramov Ivić, Milka PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1577 AB - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil. PB - Wiley-Blackwell, Malden T2 - Electroanalysis T1 - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode VL - 26 IS - 5 SP - 893 EP - 897 DO - 10.1002/elan.201400034 ER -
@article{ author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša Ž. and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan D. and Avramov Ivić, Milka", year = "2014", abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.", publisher = "Wiley-Blackwell, Malden", journal = "Electroanalysis", title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode", volume = "26", number = "5", pages = "893-897", doi = "10.1002/elan.201400034" }
Mladenović, A. R., Mijin, D., Drmanić, S. Ž., Vajs, V., Jovanović, V. M., Petrović, S. D.,& Avramov Ivić, M.. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis Wiley-Blackwell, Malden., 26(5), 893-897. https://doi.org/10.1002/elan.201400034
Mladenović AR, Mijin D, Drmanić SŽ, Vajs V, Jovanović VM, Petrović SD, Avramov Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis. 2014;26(5):893-897. doi:10.1002/elan.201400034 .
Mladenović, Aleksandar R., Mijin, Dušan, Drmanić, Saša Ž., Vajs, Vlatka, Jovanović, Vladislava M., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" in Electroanalysis, 26, no. 5 (2014):893-897, https://doi.org/10.1002/elan.201400034 . .