Приказ основних података о документу

dc.creatorStojanović, Milovan
dc.creatorDžambaski, Zdravko
dc.creatorBondžić, Bojan
dc.creatorAleksić, Jovana
dc.creatorBaranac-Stojanović, Marija
dc.date.accessioned2019-01-30T17:42:20Z
dc.date.available2019-01-30T17:42:20Z
dc.date.issued2014
dc.identifier.issn1385-2728
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/1565
dc.description.abstract4-Oxothiazolidine core, owing to the wide range of pharmacological activities exhibited by its derivatives, has been recognized as an important structural motif in biologically active compounds. A subclass constitutes 4-oxothiazolidines with an exocyclic C=C double bond at the C(2)-position. Some of these derivatives are registered as active substances for the treatment of various diseases, such as Ralitoline, an antiepileptic, Etozolin, a diuretic, and Piprozolin, a choleretic. The exocyclic C=C double bond in these compounds contains one or two electron-accepting groups at its other end, so that they also belong to the class of the so-called push-pull alkenes. In the case of the nitrogen-unsubstituted molecules, the enamino tautomeric form with the exocyclic double bond is stabilized by the extended electron delocalization arising from the push-pull effect. In the absence of push-pull effect, the imino form would dominate. Therefore, these compounds exhibit properties characteristic for both 4-oxothiazolidine ring and push-pull alkenes. They are also proved to be useful synthetic interamediates for the formation of various mono- and polyheterocycles. The importance of 4-oxothiazolidine derivatives is witnessed by several review articles, the latest published in 2012, mainly dealing with the chemistry and biological activity of various 2-imino, 2-oxo, 2-thioxo and 2-alkyl(aryl)-substituted compounds. The lack of a comprehensive review on 2-alkylidene-4-oxothiazolidines has prompted us to collect the literature covering their synthesis, structure, reactivity and biological activity. Derivatives with two exocyclic C=C double bonds are included, too.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172020/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Organic Chemistry
dc.subject2-Alkylidene-4-oxothiazolidineen
dc.subjectbiological activityen
dc.subjectheterocycleen
dc.subjectpush-pull alkeneen
dc.subjectreactivityen
dc.subjectstructureen
dc.subjectsynthesisen
dc.title4-Oxothiazolidines with Exocyclic C=C Double Bond(s): Synthesis, Structure, Reactions and Biological Activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојановић, Милован; Бонджић, Бојан; Баранац-Стојановиц, Марија; Aлексић, Јована; Джамбаски, Здравко;
dc.citation.volume18
dc.citation.issue9
dc.citation.spage1108
dc.citation.epage1148
dc.citation.other18(9): 1108-1148
dc.citation.rankM21
dc.identifier.doi10.2174/138527281809140624120436
dc.identifier.scopus2-s2.0-84904050417
dc.identifier.wos000338727500003
dc.type.versionpublishedVersion


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Приказ основних података о документу