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dc.creatorStanojevic, Marija
dc.creatorTrifković, Jelena
dc.creatorKostić Rajačić, Slađana
dc.creatorŠoškić, Vukić
dc.creatorTešić, Živoslav
dc.creatorMilojković-Opsenica, Dušanka
dc.date.accessioned2019-01-30T17:42:01Z
dc.date.available2019-01-30T17:42:01Z
dc.date.issued2014
dc.identifier.issn1082-6076
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1551
dc.description.abstractThe chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectarilpiperazinesen
dc.subjecthigh-performance thin-layer chromatographyen
dc.subjectlipophilicityen
dc.subjectpartial least squaresen
dc.subjectprincipal component analysisen
dc.subjectquantitative structure-retention relationshipsen
dc.titleAssessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТесиц, Зивослав; Станојевиц, Марија; Соскиц, Вукиц; Костић Рајачић, Слађана; Трифковиц, Јелена; Милојковиц-Опсеница, Дусанка;
dc.citation.volume37
dc.citation.issue20
dc.citation.spage2814
dc.citation.epage2828
dc.citation.other37(20): 2814-2828
dc.citation.rankM23
dc.identifier.doi10.1080/10826076.2014.907112
dc.identifier.rcubConv_3165
dc.identifier.scopus2-s2.0-84903212960
dc.identifier.wos000337971200002
dc.type.versionpublishedVersion


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