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An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol

Thumbnail
2014
1538.pdf (2.075Mb)
Autori
Ilic, Budimir S.
Kocic, Branislava D.
Ciric, Vojislav M.
Cvetković, Olga
Miladinovic, Dragoljub L.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
The chemical composition and antibacterial activity of Thymus glabrescens Willd. (Lamiaceae) essential oil were examined, as well as the association between it and chloramphenicol. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, individually and in combination with chloramphenicol, were also determined. The interactions of the essential oil, geraniol, and thymol with chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods. Oxygenated monoterpenes were the most abundant compound class in the oil, with geraniol (22.33%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotic and thymol. A combination of T. glabrescens oil and chloramphenicol produced a strong synergistic interaction (FIC indices in the range 0.21-0.87) and... a substantial reduction of the MIC value of chloramphenicol, thus minimizing its adverse side effects. The combinations geraniol-chloramphenicol and thymol-chloramphenicol produced synergistic interaction to a greater extent, compared with essential oil-chloramphenicol association, which may indicate that the activity of the thyme oil could be attributed to the presence of significant concentrations of geraniol and thymol.

Izvor:
Scientific World Journal, 2014
Izdavač:
  • Hindawi Publishing Corporation, New York
Projekti:
  • Električni proboj gasova, površinski procesi i primene (RS-171025)
  • Geohemijska ispitivanja sedimentnih stena - fosilna goriva i zagađivači životne sredine (RS-176006)

DOI: 10.1155/2014/826219

ISSN: 1537-744X

PubMed: 24616649

WoS: 000330894700001

Scopus: 2-s2.0-84896822340
[ Google Scholar ]
15
10
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1540
Kolekcije
  • Radovi istraživača / Researchers' publications
Institucija
IHTM

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