Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations
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2014
Authors
Pejić, Nataša
Blagojević, Slavica

Sarap, Natasa B.

Maksimović, Jelena

Anić, Slobodan
Čupić, Željko

Kolar-Anić, Ljiljana

Article (Published version)

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Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
Keywords:
Dushman reaction / Kinetic methods / Perturbations / PiroxicamSource:
Helvetica Chimica Acta, 2014, 97, 1, 47-55Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
Funding / projects:
- Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
- Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden (RS-43009)
DOI: 10.1002/hlca.201300109
ISSN: 0018-019X
WoS: 000330865900004
Scopus: 2-s2.0-84892760651
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IHTMTY - JOUR AU - Pejić, Nataša AU - Blagojević, Slavica AU - Sarap, Natasa B. AU - Maksimović, Jelena AU - Anić, Slobodan AU - Čupić, Željko AU - Kolar-Anić, Ljiljana PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1539 AB - Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Helvetica Chimica Acta T1 - Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations VL - 97 IS - 1 SP - 47 EP - 55 DO - 10.1002/hlca.201300109 ER -
@article{ author = "Pejić, Nataša and Blagojević, Slavica and Sarap, Natasa B. and Maksimović, Jelena and Anić, Slobodan and Čupić, Željko and Kolar-Anić, Ljiljana", year = "2014", abstract = "Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Helvetica Chimica Acta", title = "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations", volume = "97", number = "1", pages = "47-55", doi = "10.1002/hlca.201300109" }
Pejić, N., Blagojević, S., Sarap, N. B., Maksimović, J., Anić, S., Čupić, Ž.,& Kolar-Anić, L.. (2014). Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta Wiley-V C H Verlag Gmbh, Weinheim., 97(1), 47-55. https://doi.org/10.1002/hlca.201300109
Pejić N, Blagojević S, Sarap NB, Maksimović J, Anić S, Čupić Ž, Kolar-Anić L. Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta. 2014;97(1):47-55. doi:10.1002/hlca.201300109 .
Pejić, Nataša, Blagojević, Slavica, Sarap, Natasa B., Maksimović, Jelena, Anić, Slobodan, Čupić, Željko, Kolar-Anić, Ljiljana, "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations" in Helvetica Chimica Acta, 97, no. 1 (2014):47-55, https://doi.org/10.1002/hlca.201300109 . .