Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
Keywords:
Dushman reaction / Kinetic methods / Perturbations / Piroxicam
TY - JOUR
AU - Pejić, Nataša
AU - Blagojević, Slavica
AU - Sarap, Natasa B.
AU - Maksimović, Jelena
AU - Anić, Slobodan
AU - Čupić, Željko
AU - Kolar-Anić, Ljiljana
PY - 2014
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1539
AB - Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
PB - Wiley-V C H Verlag Gmbh, Weinheim
T2 - Helvetica Chimica Acta
T1 - Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations
VL - 97
IS - 1
SP - 47
EP - 55
DO - 10.1002/hlca.201300109
ER -
@article{
author = "Pejić, Nataša and Blagojević, Slavica and Sarap, Natasa B. and Maksimović, Jelena and Anić, Slobodan and Čupić, Željko and Kolar-Anić, Ljiljana",
year = "2014",
abstract = "Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Helvetica Chimica Acta",
title = "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations",
volume = "97",
number = "1",
pages = "47-55",
doi = "10.1002/hlca.201300109"
}
Pejić, N., Blagojević, S., Sarap, N. B., Maksimović, J., Anić, S., Čupić, Ž.,& Kolar-Anić, L.. (2014). Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta
Wiley-V C H Verlag Gmbh, Weinheim., 97(1), 47-55.
https://doi.org/10.1002/hlca.201300109
Pejić N, Blagojević S, Sarap NB, Maksimović J, Anić S, Čupić Ž, Kolar-Anić L. Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta. 2014;97(1):47-55.
doi:10.1002/hlca.201300109 .
Pejić, Nataša, Blagojević, Slavica, Sarap, Natasa B., Maksimović, Jelena, Anić, Slobodan, Čupić, Željko, Kolar-Anić, Ljiljana, "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations" in Helvetica Chimica Acta, 97, no. 1 (2014):47-55,
https://doi.org/10.1002/hlca.201300109 . .
