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Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations

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2014
Authors
Pejić, Nataša
Blagojević, Slavica
Sarap, Natasa B.
Maksimović, Jelena
Anić, Slobodan
Čupić, Željko
Kolar-Anić, Ljiljana
Article (Published version)
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Abstract
Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
Keywords:
Dushman reaction / Kinetic methods / Perturbations / Piroxicam
Source:
Helvetica Chimica Acta, 2014, 97, 1, 47-55
Publisher:
  • Wiley-V C H Verlag Gmbh, Weinheim
Projects:
  • Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
  • Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden (RS-43009)

DOI: 10.1002/hlca.201300109

ISSN: 0018-019X

WoS: 000330865900004

Scopus: 2-s2.0-84892760651
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1539
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