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dc.creatorTrifunović, Snežana
dc.creatorIsaković, Anđelka M.
dc.creatorIsaković, Aleksandra
dc.creatorVučković, Ivan
dc.creatorMandić, Boris
dc.creatorNovaković, Miroslav
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan
dc.creatorTrajković, Vladimir
dc.date.accessioned2019-01-30T17:41:40Z
dc.date.available2019-01-30T17:41:40Z
dc.date.issued2014
dc.identifier.issn0032-0943
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1534
dc.description.abstractFurther phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.en
dc.publisherGeorg Thieme Verlag Kg, Stuttgart
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.rightsrestrictedAccess
dc.sourcePlanta Medica
dc.subjectAchillea clavennae L.en
dc.subjectAsteraceaeen
dc.subjectsesquiterpene lactonesen
dc.subjectiso-seco-guaianolideen
dc.subjectNMRen
dc.subjectcytotoxicityen
dc.subjectapoptosisen
dc.titleIsolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennaeen
dc.typearticle
dc.rights.licenseARR
dc.citation.volume80
dc.citation.issue4
dc.citation.spage297
dc.citation.epage305
dc.citation.other80(4): 297-305
dc.citation.rankM21
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3120]
dc.identifier.pmid24510367
dc.identifier.doi10.1055/s-0033-1360312
dc.identifier.rcubConv_3123
dc.identifier.scopus2-s2.0-84895928430
dc.identifier.wos000332395000008
dc.type.versionpublishedVersion


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