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Novel anthraquinone based chalcone analogues containing an imine fragment: Synthesis, cytotoxicity and anti-angiogenic activity

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2014
Authors
Kolundzija, Branka
Markovic, Violeta
Stanojković, Tatjana
Joksovic, Ljubinka
Matić, Ivana Z.
Todorović, Nina
Nikolic, Marijana
Joksovic, Milan D.
Article (Published version)
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Abstract
A new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11 mu M. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect.
Keywords:
Chalcone / Anthraquinone / cytotoxicity / Angiogenesis
Source:
Bioorganic and Medicinal Chemistry Letters, 2014, 24, 1, 65-71
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Projects:
  • Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes (RS-172016)
  • Biological response modifiers in physiological and pathological conditions (RS-175011)

DOI: 10.1016/j.bmcl.2013.11.075

ISSN: 0960-894X

PubMed: 24332490

WoS: 000329114200008

Scopus: 2-s2.0-84891488134
[ Google Scholar ]
33
30
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1523
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IHTM

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