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dc.creatorHmuda, Sleem
dc.creatorTrišović, Nemanja
dc.creatorRogan, Jelena R.
dc.creatorPoleti, Dejan
dc.creatorVitnik, Željko
dc.creatorVitnik, Vesna
dc.creatorValentić, Nataša V.
dc.creatorBozic, Biljana
dc.creatorUšćumlić, Gordana
dc.date.accessioned2019-01-30T17:41:16Z
dc.date.available2019-01-30T17:41:16Z
dc.date.issued2014
dc.identifier.issn0026-9247
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1518
dc.description.abstractTwo new series of hydantoin derivatives, 3-(4-substituted benzyl)-5,5-diphenyl- and 3-(4-substituted benzyl)-5-ethyl-5-phenylhydantoins, were synthesized and their antiproliferative activity was tested against human colon cancer HCT-116 and breast cancer MDA-MB-231 cell lines. The presence of different substituents on both hydantoin and benzyl moieties changed the antiproliferative activity of the investigated hydantoins, whereby most of the compounds showed superior antiproliferative activity against MDA-MB-231 than against the HCT-116 cell line. The structure of three compounds was studied by single-crystal X-ray diffraction. The general structural characteristic is the presence of N-H center dot center dot center dot O hydrogen bonds in crystal packings. The molecular geometry and bonding features of the investigated hydantoins in the ground states were calculated using the density functional method. The relationship between structure and antiproliferative activity was discussed. The data presented in this investigation afford guidelines for the preparation of new hydantoin derivatives with greater antiproliferative activity.en
dc.publisherSpringer Wien, Wien
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsrestrictedAccess
dc.sourceMonatshefte Fur Chemie
dc.subjectHydantoinen
dc.subjectAntiproliferative activityen
dc.subjectX-ray structure determinationen
dc.subjectQuantum chemical calculationsen
dc.subjectNatural bond orbital analysisen
dc.titleNew derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculationsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБозиц, Биљана; Витник, Жељко; Витник, Весна; Усцумлиц, Гордана; Валентиц, Натаса; Полети, Дејан; Роган, Јелена; Трисовиц, Немања П.; Хмуда, Слеем;
dc.citation.volume145
dc.citation.issue5
dc.citation.spage821
dc.citation.epage833
dc.citation.other145(5): 821-833
dc.citation.rankM22
dc.identifier.doi10.1007/s00706-013-1149-6
dc.identifier.rcubConv_3142
dc.identifier.scopus2-s2.0-84899649174
dc.identifier.wos000334511300014
dc.type.versionpublishedVersion


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