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Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions

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2014
Authors
Jevtic, Dubravka R.
Avramov Ivić, Milka
Reljin, Irini S.
Reljin, Branimir D.
Plavec, Goran I.
Petrović, Slobodan D.
Mijin, Dušan
Article (Published version)
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Abstract
The automated, computer-aided method for differentiation and classification of malignant (M) from benign (B) cases, by analyzing the UV/VIS spectra of pleural effusions is described. It was shown that by two independent objective features, the maximum of Katz fractal dimension (KFDmax) and the area under normalized UV/VIS absorbance curve (Area), highly reliable M-B classification is possible. In the Area-KFDmax space M and B samples are linearly separable permitting thus the use of linear support vector machine as a classification tool. By analyzing 104 samples of UV/VIS spectra of pleural effusions (88 M and 16 B) collected from patients at the Clinic for Lung Diseases and Tuberculosis, Military Medical Academy in Belgrade, the accuracy of 95.45% for M cases and 100% for B cases are obtained by using the proposed method. It was shown that by applying some modifications, which are suggested in the paper, the accuracy of 100% for M cases can be reached.
Keywords:
Pleural effusions / Malignancy / Katz fractal dimension / UV/VIS diagnostic method / Clinical praxis
Source:
Physica A: Statistical Mechanics and its Applications, 2014, 403, 206-216
Publisher:
  • Elsevier Science Bv, Amsterdam
Projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
  • Development of embedded systems with connected services and digital technology (RS-44009)

DOI: 10.1016/j.physa.2014.02.026

ISSN: 0378-4371

WoS: 000334085700022

Scopus: 2-s2.0-84897696030
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1516
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IHTM

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